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Age-related deterioration of performance and increase of cortex activity comparing time- versus item-controlled fNIRS measurement

In our aging society, research into neurodegenerative processes is of great interest. Thereby, cortical activation under different neurocognitive conditions is considered to be a promising predictor. Against this background, the executive functions of a total of 250 healthy older adults (53–84 years...

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Autores principales: Blum, Leonore, Rosenbaum, David, Röben, Benjamin, Dehnen, Katja, Maetzler, Walter, Suenkel, Ulrike, Fallgatter, Andreas J., Ehlis, Ann-Christine, Metzger, Florian G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7991654/
https://www.ncbi.nlm.nih.gov/pubmed/33762595
http://dx.doi.org/10.1038/s41598-021-85762-w
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author Blum, Leonore
Rosenbaum, David
Röben, Benjamin
Dehnen, Katja
Maetzler, Walter
Suenkel, Ulrike
Fallgatter, Andreas J.
Ehlis, Ann-Christine
Metzger, Florian G.
author_facet Blum, Leonore
Rosenbaum, David
Röben, Benjamin
Dehnen, Katja
Maetzler, Walter
Suenkel, Ulrike
Fallgatter, Andreas J.
Ehlis, Ann-Christine
Metzger, Florian G.
author_sort Blum, Leonore
collection PubMed
description In our aging society, research into neurodegenerative processes is of great interest. Thereby, cortical activation under different neurocognitive conditions is considered to be a promising predictor. Against this background, the executive functions of a total of 250 healthy older adults (53–84 years) have been investigated using the Trail Making Test (TMT) and functional near-infrared spectroscopy in a block design. We investigated effects of age on the performance and cortical blood oxygenation during the TMT. Since it is assumed that older people may compensate for cognitive deficits by slowing their processing speed, we additionally analyzed the cortical blood oxygenation per solved item. Our results showed a significant decrease in processing speed in older participants compared to middle-aged individuals, however, also lower error rates during TMT part A. On a neurophysiological level, we observed increased cortical blood oxygenation in the older participants when completing the TMT. Finally, with respect to the combined measurement (O(2)Hb/item), no significantly higher hemodynamic cortical response per item was found within the older participants. The results confirm a deterioration of cognitive performance and an increase of cortical activity with increasing age. The findings are discussed in the light of current research.
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spelling pubmed-79916542021-03-26 Age-related deterioration of performance and increase of cortex activity comparing time- versus item-controlled fNIRS measurement Blum, Leonore Rosenbaum, David Röben, Benjamin Dehnen, Katja Maetzler, Walter Suenkel, Ulrike Fallgatter, Andreas J. Ehlis, Ann-Christine Metzger, Florian G. Sci Rep Article In our aging society, research into neurodegenerative processes is of great interest. Thereby, cortical activation under different neurocognitive conditions is considered to be a promising predictor. Against this background, the executive functions of a total of 250 healthy older adults (53–84 years) have been investigated using the Trail Making Test (TMT) and functional near-infrared spectroscopy in a block design. We investigated effects of age on the performance and cortical blood oxygenation during the TMT. Since it is assumed that older people may compensate for cognitive deficits by slowing their processing speed, we additionally analyzed the cortical blood oxygenation per solved item. Our results showed a significant decrease in processing speed in older participants compared to middle-aged individuals, however, also lower error rates during TMT part A. On a neurophysiological level, we observed increased cortical blood oxygenation in the older participants when completing the TMT. Finally, with respect to the combined measurement (O(2)Hb/item), no significantly higher hemodynamic cortical response per item was found within the older participants. The results confirm a deterioration of cognitive performance and an increase of cortical activity with increasing age. The findings are discussed in the light of current research. Nature Publishing Group UK 2021-03-24 /pmc/articles/PMC7991654/ /pubmed/33762595 http://dx.doi.org/10.1038/s41598-021-85762-w Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Blum, Leonore
Rosenbaum, David
Röben, Benjamin
Dehnen, Katja
Maetzler, Walter
Suenkel, Ulrike
Fallgatter, Andreas J.
Ehlis, Ann-Christine
Metzger, Florian G.
Age-related deterioration of performance and increase of cortex activity comparing time- versus item-controlled fNIRS measurement
title Age-related deterioration of performance and increase of cortex activity comparing time- versus item-controlled fNIRS measurement
title_full Age-related deterioration of performance and increase of cortex activity comparing time- versus item-controlled fNIRS measurement
title_fullStr Age-related deterioration of performance and increase of cortex activity comparing time- versus item-controlled fNIRS measurement
title_full_unstemmed Age-related deterioration of performance and increase of cortex activity comparing time- versus item-controlled fNIRS measurement
title_short Age-related deterioration of performance and increase of cortex activity comparing time- versus item-controlled fNIRS measurement
title_sort age-related deterioration of performance and increase of cortex activity comparing time- versus item-controlled fnirs measurement
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7991654/
https://www.ncbi.nlm.nih.gov/pubmed/33762595
http://dx.doi.org/10.1038/s41598-021-85762-w
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