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A Pilot Study Investigating the Use of Regional Oxygen Saturation as a Predictor of Ischemic Wound Healing Outcome after Endovascular Treatment in Patients with Chronic Limb-Threatening Ischemia

Objective: To determine the prognostic value of regional tissue oxygenation saturation (rSO(2)) for ulcer healing after endovascular treatment (EVT) of peripheral arterial disease (PAD). Materials and Methods: Among PAD patients, 34 patients with chronic limb-threatening ischemia underwent EVT for l...

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Detalles Bibliográficos
Autores principales: Kayama, Takafumi, Sano, Masaki, Inuzuka, Kazunori, Katahashi, Kazuto, Yata, Tatsuro, Yamanaka, Yuta, Naruse, Ena, Yamamoto, Naoto, Takeuchi, Hiroya, Unno, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese College of Angiology / The Japanese Society for Vascular Surgery / Japanese Society of Phlebology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7991714/
https://www.ncbi.nlm.nih.gov/pubmed/33786096
http://dx.doi.org/10.3400/avd.oa.20-00132
Descripción
Sumario:Objective: To determine the prognostic value of regional tissue oxygenation saturation (rSO(2)) for ulcer healing after endovascular treatment (EVT) of peripheral arterial disease (PAD). Materials and Methods: Among PAD patients, 34 patients with chronic limb-threatening ischemia underwent EVT for limb salvage. We retrospectively analyzed the cutoff rSO(2) values on postoperative day 1 to predict ulcer healing and patient prognosis. Skin perfusion pressure (SPP) and transcutaneous oxygen pressure (TcPO(2)) were also used to assess wound healing. Results: A finger-mounted tissue oximeter can easily measure rSO(2) on the dorsal foot. Among the 34 patients, the ulcer healed in 25, and no changes were observed in 2 patients at 1 month after EVT. However, 7 patients needed major amputation at the same time. Wound healing was achieved in all patients with rSO(2)≥50%. With this cutoff, the sensitivity and specificity of the new device for wound healing were 100% and 64%, respectively. In all the wound healing cases, SPP was ≥45 mmHg, and TcPO(2) was ≥40 mmHg. Conclusion: To assess limb ischemia, rSO(2) can be measured quickly and easily using this device. We suggest that an rSO(2)>50% shows good prognosis for ulcer healing.