Cargando…

A Pilot Study Investigating the Use of Regional Oxygen Saturation as a Predictor of Ischemic Wound Healing Outcome after Endovascular Treatment in Patients with Chronic Limb-Threatening Ischemia

Objective: To determine the prognostic value of regional tissue oxygenation saturation (rSO(2)) for ulcer healing after endovascular treatment (EVT) of peripheral arterial disease (PAD). Materials and Methods: Among PAD patients, 34 patients with chronic limb-threatening ischemia underwent EVT for l...

Descripción completa

Detalles Bibliográficos
Autores principales: Kayama, Takafumi, Sano, Masaki, Inuzuka, Kazunori, Katahashi, Kazuto, Yata, Tatsuro, Yamanaka, Yuta, Naruse, Ena, Yamamoto, Naoto, Takeuchi, Hiroya, Unno, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese College of Angiology / The Japanese Society for Vascular Surgery / Japanese Society of Phlebology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7991714/
https://www.ncbi.nlm.nih.gov/pubmed/33786096
http://dx.doi.org/10.3400/avd.oa.20-00132
_version_ 1783669225852764160
author Kayama, Takafumi
Sano, Masaki
Inuzuka, Kazunori
Katahashi, Kazuto
Yata, Tatsuro
Yamanaka, Yuta
Naruse, Ena
Yamamoto, Naoto
Takeuchi, Hiroya
Unno, Naoki
author_facet Kayama, Takafumi
Sano, Masaki
Inuzuka, Kazunori
Katahashi, Kazuto
Yata, Tatsuro
Yamanaka, Yuta
Naruse, Ena
Yamamoto, Naoto
Takeuchi, Hiroya
Unno, Naoki
author_sort Kayama, Takafumi
collection PubMed
description Objective: To determine the prognostic value of regional tissue oxygenation saturation (rSO(2)) for ulcer healing after endovascular treatment (EVT) of peripheral arterial disease (PAD). Materials and Methods: Among PAD patients, 34 patients with chronic limb-threatening ischemia underwent EVT for limb salvage. We retrospectively analyzed the cutoff rSO(2) values on postoperative day 1 to predict ulcer healing and patient prognosis. Skin perfusion pressure (SPP) and transcutaneous oxygen pressure (TcPO(2)) were also used to assess wound healing. Results: A finger-mounted tissue oximeter can easily measure rSO(2) on the dorsal foot. Among the 34 patients, the ulcer healed in 25, and no changes were observed in 2 patients at 1 month after EVT. However, 7 patients needed major amputation at the same time. Wound healing was achieved in all patients with rSO(2)≥50%. With this cutoff, the sensitivity and specificity of the new device for wound healing were 100% and 64%, respectively. In all the wound healing cases, SPP was ≥45 mmHg, and TcPO(2) was ≥40 mmHg. Conclusion: To assess limb ischemia, rSO(2) can be measured quickly and easily using this device. We suggest that an rSO(2)>50% shows good prognosis for ulcer healing.
format Online
Article
Text
id pubmed-7991714
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Japanese College of Angiology / The Japanese Society for Vascular Surgery / Japanese Society of Phlebology
record_format MEDLINE/PubMed
spelling pubmed-79917142021-03-29 A Pilot Study Investigating the Use of Regional Oxygen Saturation as a Predictor of Ischemic Wound Healing Outcome after Endovascular Treatment in Patients with Chronic Limb-Threatening Ischemia Kayama, Takafumi Sano, Masaki Inuzuka, Kazunori Katahashi, Kazuto Yata, Tatsuro Yamanaka, Yuta Naruse, Ena Yamamoto, Naoto Takeuchi, Hiroya Unno, Naoki Ann Vasc Dis Original Article Objective: To determine the prognostic value of regional tissue oxygenation saturation (rSO(2)) for ulcer healing after endovascular treatment (EVT) of peripheral arterial disease (PAD). Materials and Methods: Among PAD patients, 34 patients with chronic limb-threatening ischemia underwent EVT for limb salvage. We retrospectively analyzed the cutoff rSO(2) values on postoperative day 1 to predict ulcer healing and patient prognosis. Skin perfusion pressure (SPP) and transcutaneous oxygen pressure (TcPO(2)) were also used to assess wound healing. Results: A finger-mounted tissue oximeter can easily measure rSO(2) on the dorsal foot. Among the 34 patients, the ulcer healed in 25, and no changes were observed in 2 patients at 1 month after EVT. However, 7 patients needed major amputation at the same time. Wound healing was achieved in all patients with rSO(2)≥50%. With this cutoff, the sensitivity and specificity of the new device for wound healing were 100% and 64%, respectively. In all the wound healing cases, SPP was ≥45 mmHg, and TcPO(2) was ≥40 mmHg. Conclusion: To assess limb ischemia, rSO(2) can be measured quickly and easily using this device. We suggest that an rSO(2)>50% shows good prognosis for ulcer healing. Japanese College of Angiology / The Japanese Society for Vascular Surgery / Japanese Society of Phlebology 2021-03-25 /pmc/articles/PMC7991714/ /pubmed/33786096 http://dx.doi.org/10.3400/avd.oa.20-00132 Text en © 2021 The Editorial Committee of Annals of Vascular Diseases. http://creativecommons.org/licenses/by/2.5/ This article is distributed under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided the credit of the original work, a link to the license, and indication of any change are properly given, and the original work is not used for commercial purposes. Remixed or transformed contributions must be distributed under the same license as the original.
spellingShingle Original Article
Kayama, Takafumi
Sano, Masaki
Inuzuka, Kazunori
Katahashi, Kazuto
Yata, Tatsuro
Yamanaka, Yuta
Naruse, Ena
Yamamoto, Naoto
Takeuchi, Hiroya
Unno, Naoki
A Pilot Study Investigating the Use of Regional Oxygen Saturation as a Predictor of Ischemic Wound Healing Outcome after Endovascular Treatment in Patients with Chronic Limb-Threatening Ischemia
title A Pilot Study Investigating the Use of Regional Oxygen Saturation as a Predictor of Ischemic Wound Healing Outcome after Endovascular Treatment in Patients with Chronic Limb-Threatening Ischemia
title_full A Pilot Study Investigating the Use of Regional Oxygen Saturation as a Predictor of Ischemic Wound Healing Outcome after Endovascular Treatment in Patients with Chronic Limb-Threatening Ischemia
title_fullStr A Pilot Study Investigating the Use of Regional Oxygen Saturation as a Predictor of Ischemic Wound Healing Outcome after Endovascular Treatment in Patients with Chronic Limb-Threatening Ischemia
title_full_unstemmed A Pilot Study Investigating the Use of Regional Oxygen Saturation as a Predictor of Ischemic Wound Healing Outcome after Endovascular Treatment in Patients with Chronic Limb-Threatening Ischemia
title_short A Pilot Study Investigating the Use of Regional Oxygen Saturation as a Predictor of Ischemic Wound Healing Outcome after Endovascular Treatment in Patients with Chronic Limb-Threatening Ischemia
title_sort pilot study investigating the use of regional oxygen saturation as a predictor of ischemic wound healing outcome after endovascular treatment in patients with chronic limb-threatening ischemia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7991714/
https://www.ncbi.nlm.nih.gov/pubmed/33786096
http://dx.doi.org/10.3400/avd.oa.20-00132
work_keys_str_mv AT kayamatakafumi apilotstudyinvestigatingtheuseofregionaloxygensaturationasapredictorofischemicwoundhealingoutcomeafterendovasculartreatmentinpatientswithchroniclimbthreateningischemia
AT sanomasaki apilotstudyinvestigatingtheuseofregionaloxygensaturationasapredictorofischemicwoundhealingoutcomeafterendovasculartreatmentinpatientswithchroniclimbthreateningischemia
AT inuzukakazunori apilotstudyinvestigatingtheuseofregionaloxygensaturationasapredictorofischemicwoundhealingoutcomeafterendovasculartreatmentinpatientswithchroniclimbthreateningischemia
AT katahashikazuto apilotstudyinvestigatingtheuseofregionaloxygensaturationasapredictorofischemicwoundhealingoutcomeafterendovasculartreatmentinpatientswithchroniclimbthreateningischemia
AT yatatatsuro apilotstudyinvestigatingtheuseofregionaloxygensaturationasapredictorofischemicwoundhealingoutcomeafterendovasculartreatmentinpatientswithchroniclimbthreateningischemia
AT yamanakayuta apilotstudyinvestigatingtheuseofregionaloxygensaturationasapredictorofischemicwoundhealingoutcomeafterendovasculartreatmentinpatientswithchroniclimbthreateningischemia
AT naruseena apilotstudyinvestigatingtheuseofregionaloxygensaturationasapredictorofischemicwoundhealingoutcomeafterendovasculartreatmentinpatientswithchroniclimbthreateningischemia
AT yamamotonaoto apilotstudyinvestigatingtheuseofregionaloxygensaturationasapredictorofischemicwoundhealingoutcomeafterendovasculartreatmentinpatientswithchroniclimbthreateningischemia
AT takeuchihiroya apilotstudyinvestigatingtheuseofregionaloxygensaturationasapredictorofischemicwoundhealingoutcomeafterendovasculartreatmentinpatientswithchroniclimbthreateningischemia
AT unnonaoki apilotstudyinvestigatingtheuseofregionaloxygensaturationasapredictorofischemicwoundhealingoutcomeafterendovasculartreatmentinpatientswithchroniclimbthreateningischemia
AT kayamatakafumi pilotstudyinvestigatingtheuseofregionaloxygensaturationasapredictorofischemicwoundhealingoutcomeafterendovasculartreatmentinpatientswithchroniclimbthreateningischemia
AT sanomasaki pilotstudyinvestigatingtheuseofregionaloxygensaturationasapredictorofischemicwoundhealingoutcomeafterendovasculartreatmentinpatientswithchroniclimbthreateningischemia
AT inuzukakazunori pilotstudyinvestigatingtheuseofregionaloxygensaturationasapredictorofischemicwoundhealingoutcomeafterendovasculartreatmentinpatientswithchroniclimbthreateningischemia
AT katahashikazuto pilotstudyinvestigatingtheuseofregionaloxygensaturationasapredictorofischemicwoundhealingoutcomeafterendovasculartreatmentinpatientswithchroniclimbthreateningischemia
AT yatatatsuro pilotstudyinvestigatingtheuseofregionaloxygensaturationasapredictorofischemicwoundhealingoutcomeafterendovasculartreatmentinpatientswithchroniclimbthreateningischemia
AT yamanakayuta pilotstudyinvestigatingtheuseofregionaloxygensaturationasapredictorofischemicwoundhealingoutcomeafterendovasculartreatmentinpatientswithchroniclimbthreateningischemia
AT naruseena pilotstudyinvestigatingtheuseofregionaloxygensaturationasapredictorofischemicwoundhealingoutcomeafterendovasculartreatmentinpatientswithchroniclimbthreateningischemia
AT yamamotonaoto pilotstudyinvestigatingtheuseofregionaloxygensaturationasapredictorofischemicwoundhealingoutcomeafterendovasculartreatmentinpatientswithchroniclimbthreateningischemia
AT takeuchihiroya pilotstudyinvestigatingtheuseofregionaloxygensaturationasapredictorofischemicwoundhealingoutcomeafterendovasculartreatmentinpatientswithchroniclimbthreateningischemia
AT unnonaoki pilotstudyinvestigatingtheuseofregionaloxygensaturationasapredictorofischemicwoundhealingoutcomeafterendovasculartreatmentinpatientswithchroniclimbthreateningischemia