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Roles of Ion and Water Channels in the Cell Death and Survival of Upper Gastrointestinal Tract Cancers

Ion and water channels were recently shown to be involved in cancer cell functions, and various transporter types have been detected in upper gastrointestinal tract (UGI) cancers. Current information on the expression and roles of these channels and transporters in the death and survival of UGI canc...

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Autores principales: Shiozaki, Atsushi, Marunaka, Yoshinori, Otsuji, Eigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7991738/
https://www.ncbi.nlm.nih.gov/pubmed/33777930
http://dx.doi.org/10.3389/fcell.2021.616933
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author Shiozaki, Atsushi
Marunaka, Yoshinori
Otsuji, Eigo
author_facet Shiozaki, Atsushi
Marunaka, Yoshinori
Otsuji, Eigo
author_sort Shiozaki, Atsushi
collection PubMed
description Ion and water channels were recently shown to be involved in cancer cell functions, and various transporter types have been detected in upper gastrointestinal tract (UGI) cancers. Current information on the expression and roles of these channels and transporters in the death and survival of UGI cancer cells was reviewed herein, and the potential of their regulation for cancer management was investigated. Esophageal cancer (EC) and gastric cancer (GC) cells and tissues express many different types of ion channels, including voltage-gated K(+), Cl(–), and Ca(2+), and transient receptor potential (TRP) channels, which regulate the progression of cancer. Aquaporin (AQP) 1, 3, and 5 are water channels that contribute to the progression of esophageal squamous cell carcinoma (ESCC) and GC. Intracellular pH regulators, including the anion exchanger (AE), sodium hydrogen exchanger (NHE), and vacuolar H(+)-ATPases (V-ATPase), also play roles in the functions of UGI cancer cells. We have previously conducted gene expression profiling and revealed that the regulatory mechanisms underlying apoptosis in ESCC cells involved various types of Cl(–) channels, Ca(2+) channels, water channels, and pH regulators (Shimizu et al., 2014; Ariyoshi et al., 2017; Shiozaki et al., 2017, 2018a; Kobayashi et al., 2018; Yamazato et al., 2018; Konishi et al., 2019; Kudou et al., 2019; Katsurahara et al., 2020, 2021; Matsumoto et al., 2021; Mitsuda et al., 2021). We have also previously demonstrated the clinicopathological and prognostic significance of their expression in ESCC patients, and shown that their pharmacological blockage and gene silencing had an impact on carcinogenesis, indicating their potential as targets for the treatment of UGI cancers. A more detailed understanding of the molecular regulatory mechanisms underlying cell death and survival of UGI cancers may result in the application of cellular physiological methods as novel therapeutic approaches.
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spelling pubmed-79917382021-03-26 Roles of Ion and Water Channels in the Cell Death and Survival of Upper Gastrointestinal Tract Cancers Shiozaki, Atsushi Marunaka, Yoshinori Otsuji, Eigo Front Cell Dev Biol Cell and Developmental Biology Ion and water channels were recently shown to be involved in cancer cell functions, and various transporter types have been detected in upper gastrointestinal tract (UGI) cancers. Current information on the expression and roles of these channels and transporters in the death and survival of UGI cancer cells was reviewed herein, and the potential of their regulation for cancer management was investigated. Esophageal cancer (EC) and gastric cancer (GC) cells and tissues express many different types of ion channels, including voltage-gated K(+), Cl(–), and Ca(2+), and transient receptor potential (TRP) channels, which regulate the progression of cancer. Aquaporin (AQP) 1, 3, and 5 are water channels that contribute to the progression of esophageal squamous cell carcinoma (ESCC) and GC. Intracellular pH regulators, including the anion exchanger (AE), sodium hydrogen exchanger (NHE), and vacuolar H(+)-ATPases (V-ATPase), also play roles in the functions of UGI cancer cells. We have previously conducted gene expression profiling and revealed that the regulatory mechanisms underlying apoptosis in ESCC cells involved various types of Cl(–) channels, Ca(2+) channels, water channels, and pH regulators (Shimizu et al., 2014; Ariyoshi et al., 2017; Shiozaki et al., 2017, 2018a; Kobayashi et al., 2018; Yamazato et al., 2018; Konishi et al., 2019; Kudou et al., 2019; Katsurahara et al., 2020, 2021; Matsumoto et al., 2021; Mitsuda et al., 2021). We have also previously demonstrated the clinicopathological and prognostic significance of their expression in ESCC patients, and shown that their pharmacological blockage and gene silencing had an impact on carcinogenesis, indicating their potential as targets for the treatment of UGI cancers. A more detailed understanding of the molecular regulatory mechanisms underlying cell death and survival of UGI cancers may result in the application of cellular physiological methods as novel therapeutic approaches. Frontiers Media S.A. 2021-03-11 /pmc/articles/PMC7991738/ /pubmed/33777930 http://dx.doi.org/10.3389/fcell.2021.616933 Text en Copyright © 2021 Shiozaki, Marunaka and Otsuji. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Shiozaki, Atsushi
Marunaka, Yoshinori
Otsuji, Eigo
Roles of Ion and Water Channels in the Cell Death and Survival of Upper Gastrointestinal Tract Cancers
title Roles of Ion and Water Channels in the Cell Death and Survival of Upper Gastrointestinal Tract Cancers
title_full Roles of Ion and Water Channels in the Cell Death and Survival of Upper Gastrointestinal Tract Cancers
title_fullStr Roles of Ion and Water Channels in the Cell Death and Survival of Upper Gastrointestinal Tract Cancers
title_full_unstemmed Roles of Ion and Water Channels in the Cell Death and Survival of Upper Gastrointestinal Tract Cancers
title_short Roles of Ion and Water Channels in the Cell Death and Survival of Upper Gastrointestinal Tract Cancers
title_sort roles of ion and water channels in the cell death and survival of upper gastrointestinal tract cancers
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7991738/
https://www.ncbi.nlm.nih.gov/pubmed/33777930
http://dx.doi.org/10.3389/fcell.2021.616933
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