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Activating Mutation of SHP2 Establishes a Tumorigenic Phonotype Through Cell-Autonomous and Non-Cell-Autonomous Mechanisms

Gain-of-function mutation of SHP2 is a central regulator in tumorigenesis and cancer progression through cell-autonomous mechanisms. Activating mutation of SHP2 in microenvironment was identified to promote cancerous transformation of hematopoietic stem cell in non-autonomous mechanisms. It is inter...

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Detalles Bibliográficos
Autores principales:	Dong, Lei, Han, Da, Meng, Xinyi, Xu, Mengchuan, Zheng, Chuwen, Xia, Qin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7991796/ https://www.ncbi.nlm.nih.gov/pubmed/33777940 http://dx.doi.org/10.3389/fcell.2021.630712

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