Targeting KRAS: The Elephant in the Room of Epithelial Cancers

Mutations of the proto-oncogene KRAS are the most frequent gain-of-function alterations found in cancer. KRAS is mutated in about 30% of all human tumors, but it could reach more than 90% in certain cancer types such as pancreatic adenocarcinoma. Although historically considered to be undruggable, a...

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Detalles Bibliográficos
Autores principales: Merz, Valeria, Gaule, Marina, Zecchetto, Camilla, Cavaliere, Alessandro, Casalino, Simona, Pesoni, Camilla, Contarelli, Serena, Sabbadini, Fabio, Bertolini, Monica, Mangiameli, Domenico, Milella, Michele, Fedele, Vita, Melisi, Davide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7991835/
https://www.ncbi.nlm.nih.gov/pubmed/33777798
http://dx.doi.org/10.3389/fonc.2021.638360

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