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Recent Advances in Producing Sugar Alcohols and Functional Sugars by Engineering Yarrowia lipolytica
The sugar alcohols and functional sugars have wide applications in food, pharmaceutical, and chemical industries. However, the smaller quantities of natural occurring sugar alcohols and functional sugars restricted their applications. The enzymatic and whole-cell catalyst production is emerging as t...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992007/ https://www.ncbi.nlm.nih.gov/pubmed/33777917 http://dx.doi.org/10.3389/fbioe.2021.648382 |
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author | Abbasi, Abdul Rahman Liu, Jinle Wang, Zhi Zhao, Anqi Ying, Hanjie Qu, Lingbo Alam, Md. Asraful Xiong, Wenlong Xu, Jingliang Lv, Yongkun |
author_facet | Abbasi, Abdul Rahman Liu, Jinle Wang, Zhi Zhao, Anqi Ying, Hanjie Qu, Lingbo Alam, Md. Asraful Xiong, Wenlong Xu, Jingliang Lv, Yongkun |
author_sort | Abbasi, Abdul Rahman |
collection | PubMed |
description | The sugar alcohols and functional sugars have wide applications in food, pharmaceutical, and chemical industries. However, the smaller quantities of natural occurring sugar alcohols and functional sugars restricted their applications. The enzymatic and whole-cell catalyst production is emerging as the predominant alternatives. The properties of Yarrowia lipolytica make it a promising sugar alcohol and functional sugar producer. However, there are still some issues to be resolved. As there exist reviews about the chemical structures, physicochemical properties, biological functions, applications, and biosynthesis of sugar alcohols and/or functional sugars in Y. lipolytica, this mini review will not only update the recent advances in enzymatic and microbial production of sugar alcohols (erythritol, D-threitol, and xylitol) and functional sugars (isomaltulose, trehalose, fructo-oligosaccharides, and galacto-oligosaccharides) by using recombinant Y. lipolytica but also focus on the studies of gene discovery, pathway engineering, expanding substrate scope, bioprocess engineering, and novel breeding methods to resolve the aforementioned issues. |
format | Online Article Text |
id | pubmed-7992007 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79920072021-03-26 Recent Advances in Producing Sugar Alcohols and Functional Sugars by Engineering Yarrowia lipolytica Abbasi, Abdul Rahman Liu, Jinle Wang, Zhi Zhao, Anqi Ying, Hanjie Qu, Lingbo Alam, Md. Asraful Xiong, Wenlong Xu, Jingliang Lv, Yongkun Front Bioeng Biotechnol Bioengineering and Biotechnology The sugar alcohols and functional sugars have wide applications in food, pharmaceutical, and chemical industries. However, the smaller quantities of natural occurring sugar alcohols and functional sugars restricted their applications. The enzymatic and whole-cell catalyst production is emerging as the predominant alternatives. The properties of Yarrowia lipolytica make it a promising sugar alcohol and functional sugar producer. However, there are still some issues to be resolved. As there exist reviews about the chemical structures, physicochemical properties, biological functions, applications, and biosynthesis of sugar alcohols and/or functional sugars in Y. lipolytica, this mini review will not only update the recent advances in enzymatic and microbial production of sugar alcohols (erythritol, D-threitol, and xylitol) and functional sugars (isomaltulose, trehalose, fructo-oligosaccharides, and galacto-oligosaccharides) by using recombinant Y. lipolytica but also focus on the studies of gene discovery, pathway engineering, expanding substrate scope, bioprocess engineering, and novel breeding methods to resolve the aforementioned issues. Frontiers Media S.A. 2021-03-11 /pmc/articles/PMC7992007/ /pubmed/33777917 http://dx.doi.org/10.3389/fbioe.2021.648382 Text en Copyright © 2021 Abbasi, Liu, Wang, Zhao, Ying, Qu, Alam, Xiong, Xu and Lv. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Abbasi, Abdul Rahman Liu, Jinle Wang, Zhi Zhao, Anqi Ying, Hanjie Qu, Lingbo Alam, Md. Asraful Xiong, Wenlong Xu, Jingliang Lv, Yongkun Recent Advances in Producing Sugar Alcohols and Functional Sugars by Engineering Yarrowia lipolytica |
title | Recent Advances in Producing Sugar Alcohols and Functional Sugars by Engineering Yarrowia lipolytica |
title_full | Recent Advances in Producing Sugar Alcohols and Functional Sugars by Engineering Yarrowia lipolytica |
title_fullStr | Recent Advances in Producing Sugar Alcohols and Functional Sugars by Engineering Yarrowia lipolytica |
title_full_unstemmed | Recent Advances in Producing Sugar Alcohols and Functional Sugars by Engineering Yarrowia lipolytica |
title_short | Recent Advances in Producing Sugar Alcohols and Functional Sugars by Engineering Yarrowia lipolytica |
title_sort | recent advances in producing sugar alcohols and functional sugars by engineering yarrowia lipolytica |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992007/ https://www.ncbi.nlm.nih.gov/pubmed/33777917 http://dx.doi.org/10.3389/fbioe.2021.648382 |
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