Visualizing Cholesterol in the Brain by On-Tissue Derivatization and Quantitative Mass Spectrometry Imaging

[Image: see text] Despite being a critical molecule in the brain, mass spectrometry imaging (MSI) of cholesterol has been under-reported compared to other lipids due to the difficulty in ionizing the sterol molecule. In the present work, we have employed an on-tissue enzyme-assisted derivatization s...

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Detalles Bibliográficos
Autores principales: Angelini, Roberto, Yutuc, Eylan, Wyatt, Mark F., Newton, Jillian, Yusuf, Fowzi A., Griffiths, Lauren, Cooze, Benjamin J., El Assad, Dana, Frache, Gilles, Rao, Wei, Allen, Luke B., Korade, Zeljka, Nguyen, Thu T. A., Rathnayake, Rathnayake A. C., Cologna, Stephanie M., Howell, Owain W., Clench, Malcolm R., Wang, Yuqin, Griffiths, William J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992047/
https://www.ncbi.nlm.nih.gov/pubmed/33687199
http://dx.doi.org/10.1021/acs.analchem.0c05399

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