Hyperinsulinemia and insulin resistance in the obese may develop as part of a homeostatic response to elevated free fatty acids: A mechanistic case-control and a population-based cohort study

BACKGROUND: It is commonly accepted that in obesity free fatty acids (FFA) cause insulin resistance and hyperglycemia, which drives hyperinsulinemia. However, hyperinsulinemia is observed in subjects with normoglycaemia and thus the paradigm above should be reevaluated. METHODS: We describe two stud...

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Detalles Bibliográficos
Autores principales: Fryk, Emanuel, Olausson, Josefin, Mossberg, Karin, Strindberg, Lena, Schmelz, Martin, Brogren, Helén, Gan, Li-Ming, Piazza, Silvano, Provenzani, Alessandro, Becattini, Barbara, Lind, Lars, Solinas, Giovanni, Jansson, Per-Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992078/
https://www.ncbi.nlm.nih.gov/pubmed/33712379
http://dx.doi.org/10.1016/j.ebiom.2021.103264

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