Negatively Charged Peptide Nanofibrils from Immunoglobulin Light Chain Sequester Viral Particles but Lack Cell-Binding and Viral Transduction-Enhancing Properties

[Image: see text] Positively charged naturally occurring or engineered peptide nanofibrils (PNF) are effective enhancers of lentiviral and retroviral transduction, an often rate-limiting step in gene transfer and gene therapy approaches. These polycationic PNF are thought to bridge the electrostatic...

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Autores principales: Schütz, Desiree, Read, Clarissa, Groß, Rüdiger, Röcker, Annika, Rode, Sascha, Annamalai, Karthikeyan, Fändrich, Marcus, Münch, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992169/
https://www.ncbi.nlm.nih.gov/pubmed/33778283
http://dx.doi.org/10.1021/acsomega.1c00068

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