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Collective Dynamics of Ion Channels on Bilayer Lipid Membranes

[Image: see text] Ion channels self-organize on cellular and organelle membranes as clusters and mutually modulate their gating behavior. It has been reported that the efficient information transfer is achieved by cooperative clustering of ion channels. To address the origin and nature of collective...

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Detalles Bibliográficos
Autores principales: Shrivastava, Rajan, Ghosh, Subhendu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992176/
https://www.ncbi.nlm.nih.gov/pubmed/33778266
http://dx.doi.org/10.1021/acsomega.0c06061
Descripción
Sumario:[Image: see text] Ion channels self-organize on cellular and organelle membranes as clusters and mutually modulate their gating behavior. It has been reported that the efficient information transfer is achieved by cooperative clustering of ion channels. To address the origin and nature of collective dynamics in ion channel clusters, a statistical mechanical model, namely, the Zimm–Bragg-type model in two dimensions with unequal weight distribution in channel–channel interactions, has been proposed. Nearest neighbor interaction along with next-nearest neighbor interaction has been considered, assuming symmetric spatial organization. The multichannel bilayer electrophysiology recordings of the voltage-dependent anion channel (VDAC) from rat brain mitochondria have been analyzed in order to test and further extend the model. The model successfully describes the multichannel gating behavior and self-organization of the VDAC cluster.