DDRE-03. IDH1-MUTANT GBM CELLS ARE HIGHLY SENSITIVE TO COMBINATION OF KDM6A/B AND HDAC INHIBITORS

Mutations in IDH1 and IDH2 genes are common in low grade gliomas and secondary GBM and are known to cause a distinct epigenetic landscape in these tumors. To interrogate the epigenetic vulnerabilities of IDH-mutant gliomas, we performed a chemical screen with inhibitors of chromatin modifiers and id...

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Detalles Bibliográficos
Autores principales: Kayabölen, Alişan, Sahin, Gizem Nur, Seker, Fidan, Cingöz, Ahmet, Isik, Bekir, Acar, Simge, Wakimoto, Hiroaki, Cahill, Daniel P, Solaroglu, Ihsan, Cribbs, Adam, Oppermann, Udo, Bagci-Onder, Tugba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Supplement Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992211/
http://dx.doi.org/10.1093/noajnl/vdab024.025

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