DDRE-17. A PHASE I CLINICAL TRIAL OF DOSE-ESCALATED METABOLIC THERAPY COMBINED WITH CONCOMITANT RADIATION THERAPY IN HIGH-GRADE GLIOMA

BACKGROUND: Animal brain-tumor models have demonstrated a synergistic interaction between radiation therapy and a ketogenic diet (KD). Metformin has in-vitro anti-cancer activity, through AMPK activation and mTOR inhibition. We sought to assess the feasibility of combined radiation, KD and metformin...

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Detalles Bibliográficos
Autores principales: Porper, Keren, Shpatz, Yael, Plotkin, Luba, Pechthold, Ronit Goldman, Talianski, Alisa, Hemi, Rina, Mardor, Yael, Jan, Elisheva, Genssin, Hili, Symon, Zvi, Yair, Anikster, Zach, Leor, Lawrence, Yaacov R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Supplement Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992220/
http://dx.doi.org/10.1093/noajnl/vdab024.039

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