DDRE-29. DE NOVO PYRIMIDINE SYNTHESIS IS A TARGETABLE VULNERABILITY IN IDH-MUTANT GLIOMA

70–90% of lower-grade gliomas and secondary glioblastomas harbor gain-of-function mutations in isocitrate dehydrogenase 1 (IDH1), causing overproduction of the oncometabolite (R)-2-hydroxyglutarate [(R)-2HG]. Although inhibitors of mutant IDH enzymes are effective in other cancers, including leukemi...

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Detalles Bibliográficos
Autores principales: Shi, Diana D, Wang, Adam C, Levitt, Michael M, Endress, Jennifer E, Xu, Min, Gao, Wenhua, Khanal, Januka, Bonal, Dennis, Kornblum, Harley I, Nguyen, Quang-De, Gradl, Stefan, Sutter, Andreas, Jeffers, Michael, Janzer, Andreas, Cahill, Daniel P, Ligon, Keith L, Abdullah, Kalil G, Harris, Isaac S, Kaelin, William G, McBrayer, Samuel K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Supplement Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992238/
http://dx.doi.org/10.1093/noajnl/vdab024.051

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