DDRE-19. PHASE 0/I TRIAL OF MYCOPHENOLATE MOFETIL COMBINED WITH RADIATION TO OVERCOME GLIOBLASTOMA TREATMENT RESISTANCE BY TARGETING DE-NOVO PURINE METABOLISM

BACKGROUND: Radiation resistance is one of the major limitations for effective control of glioblastoma. Guanosine triphosphate (GTP) supplementation promotes glioblastoma radioresistance. Conversely, GTP depletion overcomes glioblastoma radioresistance by slowing the repair of radiation-induced DNA...

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Detalles Bibliográficos
Autores principales: Umemura, Yoshie, Sun, Yilun, Junck, Larry, Leung, Denise, Kim, Michelle, Al-Holou, Wajd, Sagher, Oren, Heth, Jason, Lyssiotis, Costas, Marini, Bernard, Lawrence, Theodore, Wahl, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Supplement Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992240/
http://dx.doi.org/10.1093/noajnl/vdab024.041

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