ETMM-04. AURKA INHIBITION REPROGRAMS METABOLISM AND IS SYNTHETICALLY LETHAL WITH FATTY ACID OXIDATION INHIBITION IN GLIOBLASTOMA MODEL SYSTEMS

Aurora kinase A (AURKA) has emerged as a viable drug target for glioblastoma (GBM), the most common malignant primary brain tumor in adults with a life expectancy of 12–15 months. However, resistance to therapy remains a critical issue, which partially may be driven by reprogramming of metabolism. B...

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Detalles Bibliográficos
Autores principales: Nguyen, Trang, Shu, Chang, Shang, Enyuan, Mela, Angeliki, Humala, Nelson, Mahajan, Aayushi, Akman, Hasan, Quinzii, Catarina, Zhang, Guoan, Westhof, Mike-Andrew, Karpel-Massler, Georg, Bruce, Jeffrey, Canoll, Peter, Siegelin, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Supplement Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992246/
http://dx.doi.org/10.1093/noajnl/vdab024.060

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