DDRE-24. TARGETING PURINE METABOLISM TO OVERCOME GLIOBLASTOMA THERAPY RESISTANCE

Intratumoral genomic heterogeneity in glioblastoma (GBM) is a barrier to overcoming radiation (RT) resistance. To discover genotype-independent mediators of RT resistance, we correlated RT resistance with the concentration of approximately 700 metabolites across 23 GBM cell lines. Purine metabolites...

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Detalles Bibliográficos
Autores principales: Zhou, Weihua, Yao, Yangyang, Scott, Andrew, Wilder-Romans, Kari, Dresser, Joseph, Werner, Christian, Sun, Hanshi, Pratt, Drew, Sajjakulnukit, Peter, Zaho, Shuang, Davis, Mary, Nelson, Barbara, Halbrook, Christopher, Zhang, Li, Gatto, Francesco, Srinivasan, Sudharsan, Jairath, Neil, Correa, Luis, Umemura, Yoshie, Walker, Angela, Kachman, Maureen, Qi, Nathan, Sarkaria, Jann, Xiong, Jianping, Morgan, Meredith, Rehemtulla, Alnawaz, Castro, Maria, Lowenstein, Pedro, Chandrasekaran, Sriram, Lawrence, Theodore, Lyssiotis, Costas, Wahl, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Supplement Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992262/
http://dx.doi.org/10.1093/noajnl/vdab024.046

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