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Pulmonary vascular proliferation in patients with severe COVID-19: an autopsy study
Diffuse alveolar damage and thrombi are the most common lung histopathological lesions reported in patients with severe COVID-19. Although some studies have suggested increased pulmonary angiogenesis, the presence of vascular proliferation in COVID-19 lungs has not been well characterised. Glomerulo...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992389/ https://www.ncbi.nlm.nih.gov/pubmed/33758071 http://dx.doi.org/10.1136/thoraxjnl-2020-216714 |
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author | Pérez-Mies, Belén Gómez-Rojo, María Carretero-Barrio, Irene Bardi, Tommaso Benito, Amparo García-Cosío, Mónica Caballero, Álvaro de Pablo, Raul Galán, Juan Carlos Pestaña, David Palacios, Jose |
author_facet | Pérez-Mies, Belén Gómez-Rojo, María Carretero-Barrio, Irene Bardi, Tommaso Benito, Amparo García-Cosío, Mónica Caballero, Álvaro de Pablo, Raul Galán, Juan Carlos Pestaña, David Palacios, Jose |
author_sort | Pérez-Mies, Belén |
collection | PubMed |
description | Diffuse alveolar damage and thrombi are the most common lung histopathological lesions reported in patients with severe COVID-19. Although some studies have suggested increased pulmonary angiogenesis, the presence of vascular proliferation in COVID-19 lungs has not been well characterised. Glomeruloid-like microscopic foci and/or coalescent vascular proliferations measuring up to 2 cm were present in the lung of 14 out of 16 autopsied patients. These lesions expressed CD31, CD34 and vascular endothelial cadherin. Platelet-derived growth factor receptor-β immunohistochemistry and dual immunostaining for CD34/smooth muscle actin demonstrated the presence of pericytes. These vascular alterations may contribute to the severe and refractory hypoxaemia that is common in patients with severe COVID-19. |
format | Online Article Text |
id | pubmed-7992389 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-79923892021-03-25 Pulmonary vascular proliferation in patients with severe COVID-19: an autopsy study Pérez-Mies, Belén Gómez-Rojo, María Carretero-Barrio, Irene Bardi, Tommaso Benito, Amparo García-Cosío, Mónica Caballero, Álvaro de Pablo, Raul Galán, Juan Carlos Pestaña, David Palacios, Jose Thorax Brief Communication Diffuse alveolar damage and thrombi are the most common lung histopathological lesions reported in patients with severe COVID-19. Although some studies have suggested increased pulmonary angiogenesis, the presence of vascular proliferation in COVID-19 lungs has not been well characterised. Glomeruloid-like microscopic foci and/or coalescent vascular proliferations measuring up to 2 cm were present in the lung of 14 out of 16 autopsied patients. These lesions expressed CD31, CD34 and vascular endothelial cadherin. Platelet-derived growth factor receptor-β immunohistochemistry and dual immunostaining for CD34/smooth muscle actin demonstrated the presence of pericytes. These vascular alterations may contribute to the severe and refractory hypoxaemia that is common in patients with severe COVID-19. BMJ Publishing Group 2021-10 2021-03-23 /pmc/articles/PMC7992389/ /pubmed/33758071 http://dx.doi.org/10.1136/thoraxjnl-2020-216714 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Brief Communication Pérez-Mies, Belén Gómez-Rojo, María Carretero-Barrio, Irene Bardi, Tommaso Benito, Amparo García-Cosío, Mónica Caballero, Álvaro de Pablo, Raul Galán, Juan Carlos Pestaña, David Palacios, Jose Pulmonary vascular proliferation in patients with severe COVID-19: an autopsy study |
title | Pulmonary vascular proliferation in patients with severe COVID-19: an autopsy study |
title_full | Pulmonary vascular proliferation in patients with severe COVID-19: an autopsy study |
title_fullStr | Pulmonary vascular proliferation in patients with severe COVID-19: an autopsy study |
title_full_unstemmed | Pulmonary vascular proliferation in patients with severe COVID-19: an autopsy study |
title_short | Pulmonary vascular proliferation in patients with severe COVID-19: an autopsy study |
title_sort | pulmonary vascular proliferation in patients with severe covid-19: an autopsy study |
topic | Brief Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992389/ https://www.ncbi.nlm.nih.gov/pubmed/33758071 http://dx.doi.org/10.1136/thoraxjnl-2020-216714 |
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