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Nuclear DEK preserves hematopoietic stem cells potential via NCoR1/HDAC3-Akt1/2-mTOR axis
The oncogene DEK is found fused with the NUP214 gene creating oncoprotein DEK-NUP214 that induces acute myeloid leukemia (AML) in patients, and secreted DEK protein functions as a hematopoietic cytokine to regulate hematopoiesis; however, the intrinsic role of nuclear DEK in hematopoietic stem cells...
Autores principales: | Chen, Zhe, Huo, Dawei, Li, Lei, Liu, Zhilong, Li, Zhigang, Xu, Shuangnian, Huang, Yongxiu, Wu, Weiru, Zhou, Chengfang, Liu, Yuanyuan, Kuang, Mei, Wu, Feng, Li, Hui, Qian, Pengxu, Song, Guanbin, Wu, Xudong, Chen, Jieping, Hou, Yu |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992411/ https://www.ncbi.nlm.nih.gov/pubmed/33755722 http://dx.doi.org/10.1084/jem.20201974 |
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