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Correlation of Plasma Level of Insulin-Like Growth Factor-1 (IGF-1) with Bacterial Index on Leprosy Patients in Bali
BACKGROUND: Leprosy is an infection by Mycobacterium leprae, which influenced by cellular immunity. Leprosy tends to occur in low socio-economic and nutrition groups. Researchers try to prove the role of nutrition in the pathogenesis of leprosy. Insulin-like growth factor-1 (IGF-1) as a marker of nu...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Dermatological Association; The Korean Society for Investigative Dermatology
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992574/ https://www.ncbi.nlm.nih.gov/pubmed/33911770 http://dx.doi.org/10.5021/ad.2020.32.5.370 |
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author | Santosa, Calvin Rusyati, Luh Made Mas Adiguna, Made Swastika Praharsini, IGAA Wiraguna, AAGP Wardhana, Made |
author_facet | Santosa, Calvin Rusyati, Luh Made Mas Adiguna, Made Swastika Praharsini, IGAA Wiraguna, AAGP Wardhana, Made |
author_sort | Santosa, Calvin |
collection | PubMed |
description | BACKGROUND: Leprosy is an infection by Mycobacterium leprae, which influenced by cellular immunity. Leprosy tends to occur in low socio-economic and nutrition groups. Researchers try to prove the role of nutrition in the pathogenesis of leprosy. Insulin-like growth factor-1 (IGF-1) as a marker of nutritional status shown to play a role in cellular immunity. OBJECTIVE: To evaluate the correlation between IGF-1 with bacterial index (BI) on leprosy patients in Bali. METHODS: Cross-sectional study in Sanglah Public General Hospital, Denpasar of patients with paucibacillary (PB) and multibacillary (MB) leprosy were assessed for BI using slit-skin smear. All patients were tested for plasma IGF-1 using chemiluminescent immunometric assay Immulite. All data were analyzed using IBM SPSS ver. 24.0. The study has been approved by local Institutional Review Board with ethical clearance number 2017.02.1.0356. RESULTS: Our study involved 44 MB and 2 PB leprosy. The common age group affected was between 31~40 years old (23.9%), male (60.9%), and normal body mass index (BMI) (65.2%). Mean plasma IGF-1 level in PB leprosy was higher (91.07±0.74 ng/ml) than MB (82.74±6.44 ng/ml). The mean IGF-1 level decreases as BI increases in both groups (CI 95%=81.16~85.04; p<0.001). Pearson correlation test shows strong negative correlation (Pearson r=−0.976; p<0.001) with determinant coefficient (R(2)) showing 95.2% (p<0.001). CONCLUSION: In Balinese leprosy patients, severity of disease status measured by BI were found to be strongly correlated with the plasma IGF-1 level which may help preventing transmission in household contacts by improving nutritional status. |
format | Online Article Text |
id | pubmed-7992574 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Korean Dermatological Association; The Korean Society for Investigative Dermatology |
record_format | MEDLINE/PubMed |
spelling | pubmed-79925742021-04-27 Correlation of Plasma Level of Insulin-Like Growth Factor-1 (IGF-1) with Bacterial Index on Leprosy Patients in Bali Santosa, Calvin Rusyati, Luh Made Mas Adiguna, Made Swastika Praharsini, IGAA Wiraguna, AAGP Wardhana, Made Ann Dermatol Original Article BACKGROUND: Leprosy is an infection by Mycobacterium leprae, which influenced by cellular immunity. Leprosy tends to occur in low socio-economic and nutrition groups. Researchers try to prove the role of nutrition in the pathogenesis of leprosy. Insulin-like growth factor-1 (IGF-1) as a marker of nutritional status shown to play a role in cellular immunity. OBJECTIVE: To evaluate the correlation between IGF-1 with bacterial index (BI) on leprosy patients in Bali. METHODS: Cross-sectional study in Sanglah Public General Hospital, Denpasar of patients with paucibacillary (PB) and multibacillary (MB) leprosy were assessed for BI using slit-skin smear. All patients were tested for plasma IGF-1 using chemiluminescent immunometric assay Immulite. All data were analyzed using IBM SPSS ver. 24.0. The study has been approved by local Institutional Review Board with ethical clearance number 2017.02.1.0356. RESULTS: Our study involved 44 MB and 2 PB leprosy. The common age group affected was between 31~40 years old (23.9%), male (60.9%), and normal body mass index (BMI) (65.2%). Mean plasma IGF-1 level in PB leprosy was higher (91.07±0.74 ng/ml) than MB (82.74±6.44 ng/ml). The mean IGF-1 level decreases as BI increases in both groups (CI 95%=81.16~85.04; p<0.001). Pearson correlation test shows strong negative correlation (Pearson r=−0.976; p<0.001) with determinant coefficient (R(2)) showing 95.2% (p<0.001). CONCLUSION: In Balinese leprosy patients, severity of disease status measured by BI were found to be strongly correlated with the plasma IGF-1 level which may help preventing transmission in household contacts by improving nutritional status. The Korean Dermatological Association; The Korean Society for Investigative Dermatology 2020-10 2020-09-29 /pmc/articles/PMC7992574/ /pubmed/33911770 http://dx.doi.org/10.5021/ad.2020.32.5.370 Text en Copyright © 2020 The Korean Dermatological Association and The Korean Society for Investigative Dermatology http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Santosa, Calvin Rusyati, Luh Made Mas Adiguna, Made Swastika Praharsini, IGAA Wiraguna, AAGP Wardhana, Made Correlation of Plasma Level of Insulin-Like Growth Factor-1 (IGF-1) with Bacterial Index on Leprosy Patients in Bali |
title | Correlation of Plasma Level of Insulin-Like Growth Factor-1 (IGF-1) with Bacterial Index on Leprosy Patients in Bali |
title_full | Correlation of Plasma Level of Insulin-Like Growth Factor-1 (IGF-1) with Bacterial Index on Leprosy Patients in Bali |
title_fullStr | Correlation of Plasma Level of Insulin-Like Growth Factor-1 (IGF-1) with Bacterial Index on Leprosy Patients in Bali |
title_full_unstemmed | Correlation of Plasma Level of Insulin-Like Growth Factor-1 (IGF-1) with Bacterial Index on Leprosy Patients in Bali |
title_short | Correlation of Plasma Level of Insulin-Like Growth Factor-1 (IGF-1) with Bacterial Index on Leprosy Patients in Bali |
title_sort | correlation of plasma level of insulin-like growth factor-1 (igf-1) with bacterial index on leprosy patients in bali |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992574/ https://www.ncbi.nlm.nih.gov/pubmed/33911770 http://dx.doi.org/10.5021/ad.2020.32.5.370 |
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