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Natural History of Chronic Urticaria in Korea

BACKGROUND: Data on the natural history and prognostic variables of chronic urticaria (CU) are rare and information about spontaneous remission of CU is limited. OBJECTIVE: This study evaluated the natural history of CU and identified predictors for remission. METHODS: Total 329 Korean patients with...

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Autores principales: Chung, Bo Young, Um, Ji-young, Kang, Seok Young, Kim, Hye One, Park, Chun Wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Dermatological Association; The Korean Society for Investigative Dermatology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992631/
https://www.ncbi.nlm.nih.gov/pubmed/33911707
http://dx.doi.org/10.5021/ad.2020.32.1.38
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author Chung, Bo Young
Um, Ji-young
Kang, Seok Young
Kim, Hye One
Park, Chun Wook
author_facet Chung, Bo Young
Um, Ji-young
Kang, Seok Young
Kim, Hye One
Park, Chun Wook
author_sort Chung, Bo Young
collection PubMed
description BACKGROUND: Data on the natural history and prognostic variables of chronic urticaria (CU) are rare and information about spontaneous remission of CU is limited. OBJECTIVE: This study evaluated the natural history of CU and identified predictors for remission. METHODS: Total 329 Korean patients with CU, who had follow-ups more than 6 months after diagnosis during a 7-year period in the department of dermatology in three university hospitals were enrolled. Clinical data and laboratory findings obtained by medical records and telephone interviews were analyzed, retrospectively. RESULTS: The proportion recovered in 1, 3, and 5 years after the onset of CU was 10.8%, 18.8%, and 32.9%, respectively. The mean duration of CU was 6.3 years. There were no significant differences in median recovery time depending on sex, age group, severity of CU, and type of CU. The presence of angioedema was significantly related to CU severity. There were no differences in prognosis with respect to the presence of dermographism or angioedema. Patients with atopic dermatitis (AD) had a significantly worse prognosis than patients without a history of AD; but not in patients with the history of allergic rhinitis or asthma. Patients with abnormal laboratory findings did not differ significantly in prognosis. CONCLUSION: CU remission rate significantly differ according to the presence of AD. This study provides information about the natural course of CU of Korean patients.
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spelling pubmed-79926312021-04-27 Natural History of Chronic Urticaria in Korea Chung, Bo Young Um, Ji-young Kang, Seok Young Kim, Hye One Park, Chun Wook Ann Dermatol Original Article BACKGROUND: Data on the natural history and prognostic variables of chronic urticaria (CU) are rare and information about spontaneous remission of CU is limited. OBJECTIVE: This study evaluated the natural history of CU and identified predictors for remission. METHODS: Total 329 Korean patients with CU, who had follow-ups more than 6 months after diagnosis during a 7-year period in the department of dermatology in three university hospitals were enrolled. Clinical data and laboratory findings obtained by medical records and telephone interviews were analyzed, retrospectively. RESULTS: The proportion recovered in 1, 3, and 5 years after the onset of CU was 10.8%, 18.8%, and 32.9%, respectively. The mean duration of CU was 6.3 years. There were no significant differences in median recovery time depending on sex, age group, severity of CU, and type of CU. The presence of angioedema was significantly related to CU severity. There were no differences in prognosis with respect to the presence of dermographism or angioedema. Patients with atopic dermatitis (AD) had a significantly worse prognosis than patients without a history of AD; but not in patients with the history of allergic rhinitis or asthma. Patients with abnormal laboratory findings did not differ significantly in prognosis. CONCLUSION: CU remission rate significantly differ according to the presence of AD. This study provides information about the natural course of CU of Korean patients. The Korean Dermatological Association; The Korean Society for Investigative Dermatology 2020-02 2019-12-27 /pmc/articles/PMC7992631/ /pubmed/33911707 http://dx.doi.org/10.5021/ad.2020.32.1.38 Text en Copyright © 2020 The Korean Dermatological Association and The Korean Society for Investigative Dermatology http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Chung, Bo Young
Um, Ji-young
Kang, Seok Young
Kim, Hye One
Park, Chun Wook
Natural History of Chronic Urticaria in Korea
title Natural History of Chronic Urticaria in Korea
title_full Natural History of Chronic Urticaria in Korea
title_fullStr Natural History of Chronic Urticaria in Korea
title_full_unstemmed Natural History of Chronic Urticaria in Korea
title_short Natural History of Chronic Urticaria in Korea
title_sort natural history of chronic urticaria in korea
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992631/
https://www.ncbi.nlm.nih.gov/pubmed/33911707
http://dx.doi.org/10.5021/ad.2020.32.1.38
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