Cargando…

Mycosis Fungoides and Variants of Mycosis Fungoides: A Retrospective Study of 93 Patients in a Chinese Population at a Single Center

BACKGROUND: Mycosis fungoides (MF) is the most common types of cutaneous T cell lymphoma. It typically presents with erythematous patches and plaques in the early stage and tumors and extracutaneous involvement with possibly fatal outcomes in the late stage. To facilitate early and accurate diagnosi...

Descripción completa

Detalles Bibliográficos
Autores principales: Luo, Yixin, Liu, Zhaorui, Liu, Jie, Liu, Yuehua, Zhang, Wei, Zhang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Dermatological Association; The Korean Society for Investigative Dermatology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992633/
https://www.ncbi.nlm.nih.gov/pubmed/33911704
http://dx.doi.org/10.5021/ad.2020.32.1.14
_version_ 1783669416049770496
author Luo, Yixin
Liu, Zhaorui
Liu, Jie
Liu, Yuehua
Zhang, Wei
Zhang, Yan
author_facet Luo, Yixin
Liu, Zhaorui
Liu, Jie
Liu, Yuehua
Zhang, Wei
Zhang, Yan
author_sort Luo, Yixin
collection PubMed
description BACKGROUND: Mycosis fungoides (MF) is the most common types of cutaneous T cell lymphoma. It typically presents with erythematous patches and plaques in the early stage and tumors and extracutaneous involvement with possibly fatal outcomes in the late stage. To facilitate early and accurate diagnosis of MF, it is essential to be knowledgeable of classic and variants of this disease. However, there is limited published data in the Chinese population. OBJECTIVE: To characterize our patient group and to provide additional insight into these malignancies. METHODS: Patients diagnosed with mycosis fungoides and its variants from October 2012 to January 2018 were retrospectively analyzed. Disease-specific survival (DSS) rate and curve according to early and advanced stages were also calculated. RESULTS: The mean age at diagnosis of ninety-three MF patients was 38.9±1.73 years (range: 6~77). Forty-five males (48.4%) and 48 females (51.6 %) were included in this study. The DSS rate of early-stage MF was 98.6%, while that of advanced stage MF was 88.9%. There was a significant difference in DSS rate between early stage and advanced stage MF (p=00.042, log-rank test). The median age of 10 patients with hypopigmented MF (hMF) was 10.5 years (range: 6~28). The age of hMF was younger than that of classical MF patients (p<0.05). CONCLUSION: Early-stage MF has a better prognosis than advanced stage and hMF affects younger people than classic MF among Chinese. This study provides an insight into mycosis fungoides and its variants in a Chinese population.
format Online
Article
Text
id pubmed-7992633
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher The Korean Dermatological Association; The Korean Society for Investigative Dermatology
record_format MEDLINE/PubMed
spelling pubmed-79926332021-04-27 Mycosis Fungoides and Variants of Mycosis Fungoides: A Retrospective Study of 93 Patients in a Chinese Population at a Single Center Luo, Yixin Liu, Zhaorui Liu, Jie Liu, Yuehua Zhang, Wei Zhang, Yan Ann Dermatol Original Article BACKGROUND: Mycosis fungoides (MF) is the most common types of cutaneous T cell lymphoma. It typically presents with erythematous patches and plaques in the early stage and tumors and extracutaneous involvement with possibly fatal outcomes in the late stage. To facilitate early and accurate diagnosis of MF, it is essential to be knowledgeable of classic and variants of this disease. However, there is limited published data in the Chinese population. OBJECTIVE: To characterize our patient group and to provide additional insight into these malignancies. METHODS: Patients diagnosed with mycosis fungoides and its variants from October 2012 to January 2018 were retrospectively analyzed. Disease-specific survival (DSS) rate and curve according to early and advanced stages were also calculated. RESULTS: The mean age at diagnosis of ninety-three MF patients was 38.9±1.73 years (range: 6~77). Forty-five males (48.4%) and 48 females (51.6 %) were included in this study. The DSS rate of early-stage MF was 98.6%, while that of advanced stage MF was 88.9%. There was a significant difference in DSS rate between early stage and advanced stage MF (p=00.042, log-rank test). The median age of 10 patients with hypopigmented MF (hMF) was 10.5 years (range: 6~28). The age of hMF was younger than that of classical MF patients (p<0.05). CONCLUSION: Early-stage MF has a better prognosis than advanced stage and hMF affects younger people than classic MF among Chinese. This study provides an insight into mycosis fungoides and its variants in a Chinese population. The Korean Dermatological Association; The Korean Society for Investigative Dermatology 2020-02 2019-12-27 /pmc/articles/PMC7992633/ /pubmed/33911704 http://dx.doi.org/10.5021/ad.2020.32.1.14 Text en Copyright © 2020 The Korean Dermatological Association and The Korean Society for Investigative Dermatology http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Luo, Yixin
Liu, Zhaorui
Liu, Jie
Liu, Yuehua
Zhang, Wei
Zhang, Yan
Mycosis Fungoides and Variants of Mycosis Fungoides: A Retrospective Study of 93 Patients in a Chinese Population at a Single Center
title Mycosis Fungoides and Variants of Mycosis Fungoides: A Retrospective Study of 93 Patients in a Chinese Population at a Single Center
title_full Mycosis Fungoides and Variants of Mycosis Fungoides: A Retrospective Study of 93 Patients in a Chinese Population at a Single Center
title_fullStr Mycosis Fungoides and Variants of Mycosis Fungoides: A Retrospective Study of 93 Patients in a Chinese Population at a Single Center
title_full_unstemmed Mycosis Fungoides and Variants of Mycosis Fungoides: A Retrospective Study of 93 Patients in a Chinese Population at a Single Center
title_short Mycosis Fungoides and Variants of Mycosis Fungoides: A Retrospective Study of 93 Patients in a Chinese Population at a Single Center
title_sort mycosis fungoides and variants of mycosis fungoides: a retrospective study of 93 patients in a chinese population at a single center
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992633/
https://www.ncbi.nlm.nih.gov/pubmed/33911704
http://dx.doi.org/10.5021/ad.2020.32.1.14
work_keys_str_mv AT luoyixin mycosisfungoidesandvariantsofmycosisfungoidesaretrospectivestudyof93patientsinachinesepopulationatasinglecenter
AT liuzhaorui mycosisfungoidesandvariantsofmycosisfungoidesaretrospectivestudyof93patientsinachinesepopulationatasinglecenter
AT liujie mycosisfungoidesandvariantsofmycosisfungoidesaretrospectivestudyof93patientsinachinesepopulationatasinglecenter
AT liuyuehua mycosisfungoidesandvariantsofmycosisfungoidesaretrospectivestudyof93patientsinachinesepopulationatasinglecenter
AT zhangwei mycosisfungoidesandvariantsofmycosisfungoidesaretrospectivestudyof93patientsinachinesepopulationatasinglecenter
AT zhangyan mycosisfungoidesandvariantsofmycosisfungoidesaretrospectivestudyof93patientsinachinesepopulationatasinglecenter