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Nail Dystrophy in Patients with Atopic Dermatitis and Its Association with Disease Severity

BACKGROUND: Nail dystrophy arises from various inflammatory dermatologic diseases. However, there have been few reports on the prevalence of nail abnormality in atopic dermatitis (AD) or on the relationship of this condition with the severity of the disease. OBJECTIVE: This study was intended to det...

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Autores principales: Chung, Bo Young, Choi, Yong Won, Kim, Hye One, Park, Chun Wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Dermatological Association; The Korean Society for Investigative Dermatology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992676/
https://www.ncbi.nlm.nih.gov/pubmed/33911559
http://dx.doi.org/10.5021/ad.2019.31.2.121
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author Chung, Bo Young
Choi, Yong Won
Kim, Hye One
Park, Chun Wook
author_facet Chung, Bo Young
Choi, Yong Won
Kim, Hye One
Park, Chun Wook
author_sort Chung, Bo Young
collection PubMed
description BACKGROUND: Nail dystrophy arises from various inflammatory dermatologic diseases. However, there have been few reports on the prevalence of nail abnormality in atopic dermatitis (AD) or on the relationship of this condition with the severity of the disease. OBJECTIVE: This study was intended to determine the prevalence and types of nail abnormalities associated with AD and to evaluate the relation between nail abnormalities and the severity of AD. METHODS: AD patients aged 2 to 19 who visited the outpatient clinic were thoroughly examined for nail abnormalities. Demographic information was collected and eczema area and severity index (EASI) score for severity of AD were checked. RESULTS: A total of 235 AD patients (children and adolescents) were investigated. There were 24 (10.2%) patients with nail abnormalities: transverse groove (Beau's line) (25.0%), nail pitting (16.7%), koilonychia (16.7%), trachyonychia (12.5%), leukonychia (12.5%), brachyonychia (8.3%), melanonychia (8.3%), onychomadesis (8.3%), onychoschizia (8.3%), and onycholysis (8.3%). There was no statistically significant difference in the total EASI score associated with development of nail abnormalities (p=0.236). However, when the EASI score was confined to the lower extremities, it showed a relation to the prevalence of toe nail dystrophy (odds ratio, 1.115; 95% confidence interval, 1.014~1.316; p=0.030). CONCLUSION: Nail abnormalities in AD are thought to be caused mainly by pathologic change in the nail matrix region, and the EASI score confined to lower limbs, might be used as a predictor of toe nail changes in patients with AD.
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spelling pubmed-79926762021-04-27 Nail Dystrophy in Patients with Atopic Dermatitis and Its Association with Disease Severity Chung, Bo Young Choi, Yong Won Kim, Hye One Park, Chun Wook Ann Dermatol Original Article BACKGROUND: Nail dystrophy arises from various inflammatory dermatologic diseases. However, there have been few reports on the prevalence of nail abnormality in atopic dermatitis (AD) or on the relationship of this condition with the severity of the disease. OBJECTIVE: This study was intended to determine the prevalence and types of nail abnormalities associated with AD and to evaluate the relation between nail abnormalities and the severity of AD. METHODS: AD patients aged 2 to 19 who visited the outpatient clinic were thoroughly examined for nail abnormalities. Demographic information was collected and eczema area and severity index (EASI) score for severity of AD were checked. RESULTS: A total of 235 AD patients (children and adolescents) were investigated. There were 24 (10.2%) patients with nail abnormalities: transverse groove (Beau's line) (25.0%), nail pitting (16.7%), koilonychia (16.7%), trachyonychia (12.5%), leukonychia (12.5%), brachyonychia (8.3%), melanonychia (8.3%), onychomadesis (8.3%), onychoschizia (8.3%), and onycholysis (8.3%). There was no statistically significant difference in the total EASI score associated with development of nail abnormalities (p=0.236). However, when the EASI score was confined to the lower extremities, it showed a relation to the prevalence of toe nail dystrophy (odds ratio, 1.115; 95% confidence interval, 1.014~1.316; p=0.030). CONCLUSION: Nail abnormalities in AD are thought to be caused mainly by pathologic change in the nail matrix region, and the EASI score confined to lower limbs, might be used as a predictor of toe nail changes in patients with AD. The Korean Dermatological Association; The Korean Society for Investigative Dermatology 2019-04 2019-02-28 /pmc/articles/PMC7992676/ /pubmed/33911559 http://dx.doi.org/10.5021/ad.2019.31.2.121 Text en Copyright © 2019 The Korean Dermatological Association and The Korean Society for Investigative Dermatology http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Chung, Bo Young
Choi, Yong Won
Kim, Hye One
Park, Chun Wook
Nail Dystrophy in Patients with Atopic Dermatitis and Its Association with Disease Severity
title Nail Dystrophy in Patients with Atopic Dermatitis and Its Association with Disease Severity
title_full Nail Dystrophy in Patients with Atopic Dermatitis and Its Association with Disease Severity
title_fullStr Nail Dystrophy in Patients with Atopic Dermatitis and Its Association with Disease Severity
title_full_unstemmed Nail Dystrophy in Patients with Atopic Dermatitis and Its Association with Disease Severity
title_short Nail Dystrophy in Patients with Atopic Dermatitis and Its Association with Disease Severity
title_sort nail dystrophy in patients with atopic dermatitis and its association with disease severity
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992676/
https://www.ncbi.nlm.nih.gov/pubmed/33911559
http://dx.doi.org/10.5021/ad.2019.31.2.121
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