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The Difference in Sebum Secretion Affecting Development of Acne

BACKGROUND: Although sebum secretion is crucial for acne development, acne lesion distribution is not always similar to the topographic differences of sebum secretion. OBJECTIVE: To analyze whether sebum secretion affects acne development and distribution and to assess other factors possibly influen...

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Autores principales: Jung, In Soon, Yun, Sook Jung, Lee, Jee-Bum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Dermatological Association; The Korean Society for Investigative Dermatology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992743/
https://www.ncbi.nlm.nih.gov/pubmed/33911621
http://dx.doi.org/10.5021/ad.2019.31.4.426
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author Jung, In Soon
Yun, Sook Jung
Lee, Jee-Bum
author_facet Jung, In Soon
Yun, Sook Jung
Lee, Jee-Bum
author_sort Jung, In Soon
collection PubMed
description BACKGROUND: Although sebum secretion is crucial for acne development, acne lesion distribution is not always similar to the topographic differences of sebum secretion. OBJECTIVE: To analyze whether sebum secretion affects acne development and distribution and to assess other factors possibly influencing the relationship between acne and sebum secretion. METHODS: This single-center retrospective study included 67 acne patients and 50 controls. Acne patients were divided into 3 groups based on acne lesion distribution: T-zone dominant, U-zone dominant, and mixed groups. The secreted sebum level in each zone of acne patients was compared with that of controls. We also conducted correlation analysis between secreted sebum level and acne number, depending on the facial zone. RESULTS: No significant difference was found between acne patients and controls regarding age and sex ratio. The U-zone dominant group showed increased sebum levels compared with controls in the U-zone and whole face, but a similar result was not obtained in the T-zone dominant group. Moreover, there was a significant correlation between the number of lesions and secreted sebum level in the U-zone, but not in the T-zone. Further, there was a more significant relation in the U-zone of male and young patients. CONCLUSION: We found that increased sebum secretion compared with the condition may affect acne development, especially in the U-zone. Sex and age may also influence the relationship between acne and increased sebum secretion. Acne lesion distribution may vary from patient to patient because sebum secretion affects acne differently depending on multiple factors.
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spelling pubmed-79927432021-04-27 The Difference in Sebum Secretion Affecting Development of Acne Jung, In Soon Yun, Sook Jung Lee, Jee-Bum Ann Dermatol Original Article BACKGROUND: Although sebum secretion is crucial for acne development, acne lesion distribution is not always similar to the topographic differences of sebum secretion. OBJECTIVE: To analyze whether sebum secretion affects acne development and distribution and to assess other factors possibly influencing the relationship between acne and sebum secretion. METHODS: This single-center retrospective study included 67 acne patients and 50 controls. Acne patients were divided into 3 groups based on acne lesion distribution: T-zone dominant, U-zone dominant, and mixed groups. The secreted sebum level in each zone of acne patients was compared with that of controls. We also conducted correlation analysis between secreted sebum level and acne number, depending on the facial zone. RESULTS: No significant difference was found between acne patients and controls regarding age and sex ratio. The U-zone dominant group showed increased sebum levels compared with controls in the U-zone and whole face, but a similar result was not obtained in the T-zone dominant group. Moreover, there was a significant correlation between the number of lesions and secreted sebum level in the U-zone, but not in the T-zone. Further, there was a more significant relation in the U-zone of male and young patients. CONCLUSION: We found that increased sebum secretion compared with the condition may affect acne development, especially in the U-zone. Sex and age may also influence the relationship between acne and increased sebum secretion. Acne lesion distribution may vary from patient to patient because sebum secretion affects acne differently depending on multiple factors. The Korean Dermatological Association; The Korean Society for Investigative Dermatology 2019-08 2019-07-01 /pmc/articles/PMC7992743/ /pubmed/33911621 http://dx.doi.org/10.5021/ad.2019.31.4.426 Text en Copyright © 2019 The Korean Dermatological Association and The Korean Society for Investigative Dermatology http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Jung, In Soon
Yun, Sook Jung
Lee, Jee-Bum
The Difference in Sebum Secretion Affecting Development of Acne
title The Difference in Sebum Secretion Affecting Development of Acne
title_full The Difference in Sebum Secretion Affecting Development of Acne
title_fullStr The Difference in Sebum Secretion Affecting Development of Acne
title_full_unstemmed The Difference in Sebum Secretion Affecting Development of Acne
title_short The Difference in Sebum Secretion Affecting Development of Acne
title_sort difference in sebum secretion affecting development of acne
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992743/
https://www.ncbi.nlm.nih.gov/pubmed/33911621
http://dx.doi.org/10.5021/ad.2019.31.4.426
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