TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6

Amyotrophic lateral sclerosis (ALS) is a genetically heterogeneous neurodegenerative disease in which 97% of patients exhibit cytoplasmic aggregates containing the RNA binding protein TDP-43. Using tagged ribosome affinity purifications in Drosophila models of TDP-43 proteinopathy, we identified TDP...

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Detalles Bibliográficos
Autores principales: Lehmkuhl, Erik M., Loganathan, Suvithanandhini, Alsop, Eric, Blythe, Alexander D., Kovalik, Tina, Mortimore, Nicholas P., Barrameda, Dianne, Kueth, Chuol, Eck, Randall J., Siddegowda, Bhavani B., Joardar, Archi, Ball, Hannah, Macias, Maria E., Bowser, Robert, Van Keuren-Jensen, Kendall, Zarnescu, Daniela C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992842/
https://www.ncbi.nlm.nih.gov/pubmed/33762006
http://dx.doi.org/10.1186/s40478-021-01148-z

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