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Phase I trial of convection-enhanced delivery of IL13RA2 and EPHA2 receptor targeted cytotoxins in dogs with spontaneous intracranial gliomas

BACKGROUND: The interleukin-13 receptor alpha 2 (IL13RA2) and ephrin type A receptor 2 (EPHA2) are attractive therapeutic targets, being expressed in ~90% of canine and human gliomas, and absent in normal brain. Clinical trials using an earlier generation IL-13 based cytotoxin showed encouraging cli...

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Detalles Bibliográficos
Autores principales:	Rossmeisl, John H, Herpai, Denise, Quigley, Mindy, Cecere, Thomas E, Robertson, John L, D’Agostino, Ralph B, Hinckley, Jonathan, Tatter, Stephen B, Dickinson, Peter J, Debinski, Waldemar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Basic and Translational Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992889/ https://www.ncbi.nlm.nih.gov/pubmed/32812637 http://dx.doi.org/10.1093/neuonc/noaa196

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