Cargando…
A Case of Histoplasmosis Mimicking Primary Lung Cancer With Liver Metastasis
Histoplasmosis is usually self-limiting in healthy individuals but often fatal in immunocompromised patients. It can mimic primary lung malignancy and liver metastasis, causing a delay in appropriate therapy. We report a case of a 58-year-old male, with a 20 pack-year smoking habit, who presented wi...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992917/ https://www.ncbi.nlm.nih.gov/pubmed/33786224 http://dx.doi.org/10.7759/cureus.13517 |
_version_ | 1783669472895172608 |
---|---|
author | Fohle, Emmanuel Seth, Rishi Matta, Abhishek |
author_facet | Fohle, Emmanuel Seth, Rishi Matta, Abhishek |
author_sort | Fohle, Emmanuel |
collection | PubMed |
description | Histoplasmosis is usually self-limiting in healthy individuals but often fatal in immunocompromised patients. It can mimic primary lung malignancy and liver metastasis, causing a delay in appropriate therapy. We report a case of a 58-year-old male, with a 20 pack-year smoking habit, who presented with a three-week history of persistent fevers and productive cough with night sweats. Computed tomography (CT) scan of chest, abdomen and pelvis showed findings suggestive for primary lung malignancy associated with liver metastasis. Liver biopsy showed budding yeast. Bronchoalveolar lavage (BAL) fluid grew fungal organisms. Urine and serology were positive for histoplasmosis. Patient was pancytopenic, hence, we decided to evaluate further with a bone marrow biopsy which revealed underlying hairy cell leukemia. In the case of disseminated histoplasmosis, a high degree of suspicion towards any immunosuppressive condition should be entertained and any signs should be promptly investigated. |
format | Online Article Text |
id | pubmed-7992917 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-79929172021-03-29 A Case of Histoplasmosis Mimicking Primary Lung Cancer With Liver Metastasis Fohle, Emmanuel Seth, Rishi Matta, Abhishek Cureus Internal Medicine Histoplasmosis is usually self-limiting in healthy individuals but often fatal in immunocompromised patients. It can mimic primary lung malignancy and liver metastasis, causing a delay in appropriate therapy. We report a case of a 58-year-old male, with a 20 pack-year smoking habit, who presented with a three-week history of persistent fevers and productive cough with night sweats. Computed tomography (CT) scan of chest, abdomen and pelvis showed findings suggestive for primary lung malignancy associated with liver metastasis. Liver biopsy showed budding yeast. Bronchoalveolar lavage (BAL) fluid grew fungal organisms. Urine and serology were positive for histoplasmosis. Patient was pancytopenic, hence, we decided to evaluate further with a bone marrow biopsy which revealed underlying hairy cell leukemia. In the case of disseminated histoplasmosis, a high degree of suspicion towards any immunosuppressive condition should be entertained and any signs should be promptly investigated. Cureus 2021-02-23 /pmc/articles/PMC7992917/ /pubmed/33786224 http://dx.doi.org/10.7759/cureus.13517 Text en Copyright © 2021, Fohle et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Fohle, Emmanuel Seth, Rishi Matta, Abhishek A Case of Histoplasmosis Mimicking Primary Lung Cancer With Liver Metastasis |
title | A Case of Histoplasmosis Mimicking Primary Lung Cancer With Liver Metastasis |
title_full | A Case of Histoplasmosis Mimicking Primary Lung Cancer With Liver Metastasis |
title_fullStr | A Case of Histoplasmosis Mimicking Primary Lung Cancer With Liver Metastasis |
title_full_unstemmed | A Case of Histoplasmosis Mimicking Primary Lung Cancer With Liver Metastasis |
title_short | A Case of Histoplasmosis Mimicking Primary Lung Cancer With Liver Metastasis |
title_sort | case of histoplasmosis mimicking primary lung cancer with liver metastasis |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992917/ https://www.ncbi.nlm.nih.gov/pubmed/33786224 http://dx.doi.org/10.7759/cureus.13517 |
work_keys_str_mv | AT fohleemmanuel acaseofhistoplasmosismimickingprimarylungcancerwithlivermetastasis AT sethrishi acaseofhistoplasmosismimickingprimarylungcancerwithlivermetastasis AT mattaabhishek acaseofhistoplasmosismimickingprimarylungcancerwithlivermetastasis AT fohleemmanuel caseofhistoplasmosismimickingprimarylungcancerwithlivermetastasis AT sethrishi caseofhistoplasmosismimickingprimarylungcancerwithlivermetastasis AT mattaabhishek caseofhistoplasmosismimickingprimarylungcancerwithlivermetastasis |