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CD47 expression and CD163(+) macrophages correlated with prognosis of pancreatic neuroendocrine tumor

BACKGROUND: Recent studies have suggested the important roles of CD47 and tumor-associated macrophages in the prognosis and immunotherapy of various human malignancies. However, the clinical significance of CD47 expression and CD163+ TAMs in pancreatic neuroendocrine tumor (PanNET) remains unclear....

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Autores principales: Imam, Rami, Chang, Qing, Black, Margaret, Yu, Caroline, Cao, Wenqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992939/
https://www.ncbi.nlm.nih.gov/pubmed/33765961
http://dx.doi.org/10.1186/s12885-021-08045-7
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author Imam, Rami
Chang, Qing
Black, Margaret
Yu, Caroline
Cao, Wenqing
author_facet Imam, Rami
Chang, Qing
Black, Margaret
Yu, Caroline
Cao, Wenqing
author_sort Imam, Rami
collection PubMed
description BACKGROUND: Recent studies have suggested the important roles of CD47 and tumor-associated macrophages in the prognosis and immunotherapy of various human malignancies. However, the clinical significance of CD47 expression and CD163+ TAMs in pancreatic neuroendocrine tumor (PanNET) remains unclear. METHODS: In this study, 47 well-differentiated PanNET resection specimens were collected. CD47 expression and CD163+ macrophages were evaluated using immunohistochemistry and correlated with clinicopathologic properties. RESULTS: Positive CD47 staining was seen in all PanNETs as well as adjacent normal islets. Compared to normal islets, CD47 overexpressed in PanNETs (p = 0.0015). In the cohort, lymph node metastasis (LNM), lymphovascular invasion (LVI), and perineural invasion (PNI) were found in 36.2, 59.6, and 48.9% of the cases, respectively. Interestingly, PanNETs with LNM, LVI, or PNI had significantly lower H-score of CD47 than those without LNM (p = 0.035), LVI (p = 0.0005), or PNI (p = 0.0035). PanNETs in patients with disease progression (recurrence/death) also showed a significantly lower expression of CD47 than those without progression (p = 0.022). In contrast, CD163+ macrophage counts were significantly higher in cases with LNM, LVI, and PNI. CONCLUSIONS: Our data suggest relative low CD47 expression and high CD163+ TAMs may act as indicators for poor prognosis of PanNETs. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-021-08045-7.
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spelling pubmed-79929392021-03-25 CD47 expression and CD163(+) macrophages correlated with prognosis of pancreatic neuroendocrine tumor Imam, Rami Chang, Qing Black, Margaret Yu, Caroline Cao, Wenqing BMC Cancer Research Article BACKGROUND: Recent studies have suggested the important roles of CD47 and tumor-associated macrophages in the prognosis and immunotherapy of various human malignancies. However, the clinical significance of CD47 expression and CD163+ TAMs in pancreatic neuroendocrine tumor (PanNET) remains unclear. METHODS: In this study, 47 well-differentiated PanNET resection specimens were collected. CD47 expression and CD163+ macrophages were evaluated using immunohistochemistry and correlated with clinicopathologic properties. RESULTS: Positive CD47 staining was seen in all PanNETs as well as adjacent normal islets. Compared to normal islets, CD47 overexpressed in PanNETs (p = 0.0015). In the cohort, lymph node metastasis (LNM), lymphovascular invasion (LVI), and perineural invasion (PNI) were found in 36.2, 59.6, and 48.9% of the cases, respectively. Interestingly, PanNETs with LNM, LVI, or PNI had significantly lower H-score of CD47 than those without LNM (p = 0.035), LVI (p = 0.0005), or PNI (p = 0.0035). PanNETs in patients with disease progression (recurrence/death) also showed a significantly lower expression of CD47 than those without progression (p = 0.022). In contrast, CD163+ macrophage counts were significantly higher in cases with LNM, LVI, and PNI. CONCLUSIONS: Our data suggest relative low CD47 expression and high CD163+ TAMs may act as indicators for poor prognosis of PanNETs. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-021-08045-7. BioMed Central 2021-03-25 /pmc/articles/PMC7992939/ /pubmed/33765961 http://dx.doi.org/10.1186/s12885-021-08045-7 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Imam, Rami
Chang, Qing
Black, Margaret
Yu, Caroline
Cao, Wenqing
CD47 expression and CD163(+) macrophages correlated with prognosis of pancreatic neuroendocrine tumor
title CD47 expression and CD163(+) macrophages correlated with prognosis of pancreatic neuroendocrine tumor
title_full CD47 expression and CD163(+) macrophages correlated with prognosis of pancreatic neuroendocrine tumor
title_fullStr CD47 expression and CD163(+) macrophages correlated with prognosis of pancreatic neuroendocrine tumor
title_full_unstemmed CD47 expression and CD163(+) macrophages correlated with prognosis of pancreatic neuroendocrine tumor
title_short CD47 expression and CD163(+) macrophages correlated with prognosis of pancreatic neuroendocrine tumor
title_sort cd47 expression and cd163(+) macrophages correlated with prognosis of pancreatic neuroendocrine tumor
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992939/
https://www.ncbi.nlm.nih.gov/pubmed/33765961
http://dx.doi.org/10.1186/s12885-021-08045-7
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