Cargando…

Mitochondrial genotype alters the impact of rapamycin on the transcriptional response to nutrients in Drosophila

BACKGROUND: In addition to their well characterized role in cellular energy production, new evidence has revealed the involvement of mitochondria in diverse signaling pathways that regulate a broad array of cellular functions. The mitochondrial genome (mtDNA) encodes essential components of the oxid...

Descripción completa

Detalles Bibliográficos
Autores principales:	Santiago, John C., Boylan, Joan M., Lemieux, Faye A., Gruppuso, Philip A., Sanders, Jennifer A., Rand, David M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992956/ https://www.ncbi.nlm.nih.gov/pubmed/33761878 http://dx.doi.org/10.1186/s12864-021-07516-2

Ejemplares similares

Rapamycin Response in Tumorigenic and Non-Tumorigenic Hepatic Cell Lines
por: Jimenez, Rosa H., et al.
Publicado: (2009)

Phosphoproteomic Profiling of In Vivo Signaling in Liver by the Mammalian Target of Rapamycin Complex 1 (mTORC1)
por: Demirkan, Gokhan, et al.
Publicado: (2011)

Transcriptional changes during hepatic ischemia-reperfusion in the rat
por: Zabala, Valerie, et al.
Publicado: (2019)

Genotype and Trait Specific Responses to Rapamycin Intake in Drosophila melanogaster
por: Rohde, Palle Duun, et al.
Publicado: (2021)

Regulation of Gene Expression in Hepatic Cells by the Mammalian Target of Rapamycin (mTOR)
por: Jimenez, Rosa H., et al.
Publicado: (2010)

Rapamycin enhances survival in a Drosophila model of mitochondrial disease
por: Wang, Adrienne, et al.
Publicado: (2016)

Resveratrol Inhibits Protein Translation in Hepatic Cells
por: Villa-Cuesta, Eugenia, et al.
Publicado: (2011)

Mitochondrial-Nuclear Interactions Mediate Sex-Specific Transcriptional Profiles in Drosophila
por: Mossman, Jim A., et al.
Publicado: (2016)

Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control
por: Loewith, Robbie, et al.
Publicado: (2011)

Mitochondrial DNA Fitness Depends on Nuclear Genetic Background in Drosophila
por: Mossman, Jim A., et al.
Publicado: (2019)

The contribution of non-essential Schizosaccharomyces pombe genes to fitness in response to altered nutrient supply and target of rapamycin activity
por: Lie, Shervi, et al.
Publicado: (2018)

Mitonuclear epistasis, genotype‐by‐environment interactions, and personalized genomics of complex traits in Drosophila
por: Rand, David M., et al.
Publicado: (2018)

Drosophila larvae lacking the bcl-2 gene, buffy, are sensitive to nutrient stress, maintain increased basal target of rapamycin (Tor) signaling and exhibit characteristics of altered basal energy metabolism
por: Monserrate, Jessica P, et al.
Publicado: (2012)

Rapamycin preserves gut homeostasis during Drosophila aging
por: Fan, Xiaolan, et al.
Publicado: (2015)

Mitonuclear Interactions Mediate Transcriptional Responses to Hypoxia in Drosophila
por: Mossman, Jim A., et al.
Publicado: (2016)

Lethal Interaction of Nuclear and Mitochondrial Genotypes in Drosophila melanogaster
por: Salminen, Tiina S., et al.
Publicado: (2019)

To grow or not to grow under nutrient scarcity: Target of rapamycin-ethylene is the question
por: García, María José, et al.
Publicado: (2022)

Stability of histone post-translational modifications in samples derived from liver tissue and primary hepatic cells
por: Gruppuso, Philip A., et al.
Publicado: (2018)

Rapamycin modulates tissue aging and lifespan independently of the gut microbiota in Drosophila
por: Schinaman, Joseph M., et al.
Publicado: (2019)

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
por: Bjedov, Ivana, et al.
Publicado: (2010)

Rheb and mammalian target of rapamycin in mitochondrial homoeostasis
por: Groenewoud, Marlous J., et al.
Publicado: (2013)

Rapamycin reduces neuronal mutant huntingtin aggregation and ameliorates locomotor performance in Drosophila
por: Roth, Jonathan R., et al.
Publicado: (2023)

Chronic rapamycin treatment on the nutrient utilization and metabolism of juvenile turbot (Psetta maxima)
por: Wang, Qingchao, et al.
Publicado: (2016)

Mitochondrial genomic variation drives differential nuclear gene expression in discrete regions of Drosophila gene and protein interaction networks
por: Mossman, Jim A., et al.
Publicado: (2019)

G×G×E for Lifespan in Drosophila: Mitochondrial, Nuclear, and Dietary Interactions that Modify Longevity
por: Zhu, Chen-Tseh, et al.
Publicado: (2014)

Loss of Drosophila FMRP leads to alterations in energy metabolism and mitochondrial function
por: Weisz, Eliana D, et al.
Publicado: (2018)

Rapamycin selectively alters serum chemistry in diabetic mice
por: Tabatabai-Mir, Hooman, et al.
Publicado: (2012)

Patterns of gene expression and DNA methylation in human fetal and adult liver
por: Huse, Susan M., et al.
Publicado: (2015)

Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome
por: Glatter, Timo, et al.
Publicado: (2011)

Mitochondria as environments for the nuclear genome in Drosophila: mitonuclear G×G×E
por: Rand, David M, et al.
Publicado: (2021)

The effects of AICAR and rapamycin on mitochondrial function in immortalized mitochondrial DNA mutator murine embryonic fibroblasts
por: Delic, Vedad, et al.
Publicado: (2018)

Gut Bacteria Mediate Nutrient Availability in Drosophila Diets
por: Lesperance, Danielle N. A., et al.
Publicado: (2020)

Target of Rapamycin Complex 2 regulates cell growth via Myc in Drosophila
por: Kuo, Ying, et al.
Publicado: (2015)

The Afterlife of Interspecific Indirect Genetic Effects: Genotype Interactions Alter Litter Quality with Consequences for Decomposition and Nutrient Dynamics
por: Genung, Mark A., et al.
Publicado: (2013)

Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance
por: Ye, Lan, et al.
Publicado: (2013)

PKC downregulation upon rapamycin treatment attenuates mitochondrial disease
por: Martin-Perez, Miguel, et al.
Publicado: (2020)

Rapamycin Ameliorates Defects in Mitochondrial Fission and Mitophagy in Glioblastoma Cells
por: Lenzi, Paola, et al.
Publicado: (2021)

Cytoophidia respond to nutrient stress in Drosophila
por: Wu, Zheng, et al.
Publicado: (2019)

Nutrients, Mitochondrial Function, and Perinatal Health
por: Rodríguez-Cano, Ameyalli M, et al.
Publicado: (2020)

The Drosophila FoxA Ortholog Fork Head Regulates Growth and Gene Expression Downstream of Target of Rapamycin
por: Bülow, Margret H., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_r0qhigl0crqruhhe9lu0unoaej