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Molecular Mechanisms of the Genetic Predisposition to Acute Megakaryoblastic Leukemia in Infants With Down Syndrome

Individuals with Down syndrome are genetically predisposed to developing acute megakaryoblastic leukemia. This myeloid leukemia associated with Down syndrome (ML–DS) demonstrates a model of step-wise leukemogenesis with perturbed hematopoiesis already presenting in utero, facilitating the acquisitio...

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Detalles Bibliográficos
Autores principales:	Grimm, Juliane, Heckl, Dirk, Klusmann, Jan-Henning
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992977/ https://www.ncbi.nlm.nih.gov/pubmed/33777792 http://dx.doi.org/10.3389/fonc.2021.636633

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