Germinal center reactions in tertiary lymphoid structures associate with neoantigen burden, humoral immunity and long-term survivorship in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) has traditionally been thought of as an immunologically quiescent tumor type presumably because of a relatively low tumor mutational burden (TMB) and poor responses to checkpoint blockade therapy. However, many PDAC tumors exhibit T cell inflamed phenotypes. T...

Descripción completa

Detalles Bibliográficos
Autores principales: Gunderson, Andrew J., Rajamanickam, Venkatesh, Bui, Cynthia, Bernard, Brady, Pucilowska, Joanna, Ballesteros-Merino, Carmen, Schmidt, Mark, McCarty, Kayla, Philips, Michaela, Piening, Brian, Dubay, Christopher, Medler, Terry, Newell, Phillipa, Hansen, Paul, Tran, Eric, Tang, Ephraim, Bifulco, Carlo, Crittenden, Marka, Gough, Michael, Young, Kristina H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993148/
https://www.ncbi.nlm.nih.gov/pubmed/33796412
http://dx.doi.org/10.1080/2162402X.2021.1900635

Ejemplares similares

Ejemplares similares