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An Efficient Prognostic Immune Scoring System For Colorectal Cancer Patients With Peritoneal Metastasis

Immunoscore can accurately predict the prognosis of patients with stage I–III colorectal cancer. However, whether it can be used to predict the prognosis of colorectal cancer peritoneal metastases (CRCPM) remains to be validated. We analyzed peritoneal and ovarian metastases in 68 patients with CRCP...

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Autores principales: Zhao, Yamei, Chen, Chao, Xu, Xiaoming, Ge, Xiaoxu, Ding, Kefeng, Zheng, Shu, Wang, Jian, Sun, Lifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993154/
https://www.ncbi.nlm.nih.gov/pubmed/33796414
http://dx.doi.org/10.1080/2162402X.2021.1901464
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author Zhao, Yamei
Chen, Chao
Xu, Xiaoming
Ge, Xiaoxu
Ding, Kefeng
Zheng, Shu
Wang, Jian
Sun, Lifeng
author_facet Zhao, Yamei
Chen, Chao
Xu, Xiaoming
Ge, Xiaoxu
Ding, Kefeng
Zheng, Shu
Wang, Jian
Sun, Lifeng
author_sort Zhao, Yamei
collection PubMed
description Immunoscore can accurately predict the prognosis of patients with stage I–III colorectal cancer. However, whether it can be used to predict the prognosis of colorectal cancer peritoneal metastases (CRCPM) remains to be validated. We analyzed peritoneal and ovarian metastases in 68 patients with CRCPM. The immunoscore (IS) was based on the infiltration level of CD3+ and CD8+ T cells, whereas the TBM score was derived from the infiltration level of CD3+, CD8+, CD20+ and CD163+ cells to tumor microenvironment (TME). The predictive value of IS and TBM scores for relapse-free survival (RFS) and overall survival (OS) of patients with CRCPM was analyzed using Kaplan Meier curve and Cox multivariate models. Significant difference in the infiltration levels of different immune cell subtypes in primary lesions, peritoneal metastasis and ovarian metastasis were compared using t-test.CRCPM patients with high IS (>1), high TBM1 score (≥2) or high TBM2 score (≥2) had a significantly longer OS (IS: median OS, not reached vs 23 months, p = .0078; TBM1: not reached vs 21.5 months, p = .013; TBM2: 39.3 months vs 15.2 months, p = .001). On the other hand, patients with high IS had a trend of improved RFS (13.4 months vs 11.0 months, p = .067). However, TBM1 and TBM2 score has no predictive utility for RFS. Multivariate analysis revealed that IS, TBM1 and TBM2 can accurately predict OS, but not RFS. Finally, the infiltration level of CD3+ T cells, CD8+ T cells, CD20+ B cells, and CD68+ macrophage was significantly higher in peritoneal metastatic tissue and ovarian metastatic tissue, relative to primary tumor tissues.The IS and TBM score of peritoneal metastases could effectively predict OS of patients with CRCPM. Peritoneal metastasis of colorectal cancer decreased the infiltration level of T and B cells.
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spelling pubmed-79931542021-03-31 An Efficient Prognostic Immune Scoring System For Colorectal Cancer Patients With Peritoneal Metastasis Zhao, Yamei Chen, Chao Xu, Xiaoming Ge, Xiaoxu Ding, Kefeng Zheng, Shu Wang, Jian Sun, Lifeng Oncoimmunology Original Research Immunoscore can accurately predict the prognosis of patients with stage I–III colorectal cancer. However, whether it can be used to predict the prognosis of colorectal cancer peritoneal metastases (CRCPM) remains to be validated. We analyzed peritoneal and ovarian metastases in 68 patients with CRCPM. The immunoscore (IS) was based on the infiltration level of CD3+ and CD8+ T cells, whereas the TBM score was derived from the infiltration level of CD3+, CD8+, CD20+ and CD163+ cells to tumor microenvironment (TME). The predictive value of IS and TBM scores for relapse-free survival (RFS) and overall survival (OS) of patients with CRCPM was analyzed using Kaplan Meier curve and Cox multivariate models. Significant difference in the infiltration levels of different immune cell subtypes in primary lesions, peritoneal metastasis and ovarian metastasis were compared using t-test.CRCPM patients with high IS (>1), high TBM1 score (≥2) or high TBM2 score (≥2) had a significantly longer OS (IS: median OS, not reached vs 23 months, p = .0078; TBM1: not reached vs 21.5 months, p = .013; TBM2: 39.3 months vs 15.2 months, p = .001). On the other hand, patients with high IS had a trend of improved RFS (13.4 months vs 11.0 months, p = .067). However, TBM1 and TBM2 score has no predictive utility for RFS. Multivariate analysis revealed that IS, TBM1 and TBM2 can accurately predict OS, but not RFS. Finally, the infiltration level of CD3+ T cells, CD8+ T cells, CD20+ B cells, and CD68+ macrophage was significantly higher in peritoneal metastatic tissue and ovarian metastatic tissue, relative to primary tumor tissues.The IS and TBM score of peritoneal metastases could effectively predict OS of patients with CRCPM. Peritoneal metastasis of colorectal cancer decreased the infiltration level of T and B cells. Taylor & Francis 2021-03-22 /pmc/articles/PMC7993154/ /pubmed/33796414 http://dx.doi.org/10.1080/2162402X.2021.1901464 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Zhao, Yamei
Chen, Chao
Xu, Xiaoming
Ge, Xiaoxu
Ding, Kefeng
Zheng, Shu
Wang, Jian
Sun, Lifeng
An Efficient Prognostic Immune Scoring System For Colorectal Cancer Patients With Peritoneal Metastasis
title An Efficient Prognostic Immune Scoring System For Colorectal Cancer Patients With Peritoneal Metastasis
title_full An Efficient Prognostic Immune Scoring System For Colorectal Cancer Patients With Peritoneal Metastasis
title_fullStr An Efficient Prognostic Immune Scoring System For Colorectal Cancer Patients With Peritoneal Metastasis
title_full_unstemmed An Efficient Prognostic Immune Scoring System For Colorectal Cancer Patients With Peritoneal Metastasis
title_short An Efficient Prognostic Immune Scoring System For Colorectal Cancer Patients With Peritoneal Metastasis
title_sort efficient prognostic immune scoring system for colorectal cancer patients with peritoneal metastasis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993154/
https://www.ncbi.nlm.nih.gov/pubmed/33796414
http://dx.doi.org/10.1080/2162402X.2021.1901464
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