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Predicting Resolvin D1 Pharmacokinetics in Humans with Physiologically‐Based Pharmacokinetic Modeling

Sjögren’s syndrome (SS) is an autoimmune disease with no effective treatment options. Resolvin D1 (RvD1) belongs to a class of lipid‐based specialized pro‐resolving mediators that showed efficacy in preclinical models of SS. We developed a physiologically‐based pharmacokinetic (PBPK) model of RvD1 i...

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Detalles Bibliográficos
Autores principales:	Yellepeddi, Venkata K., Parashar, Kaustubh, Dean, Spencer M., Watt, Kevin M., Constance, Jonathan E., Baker, Olga J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993257/ https://www.ncbi.nlm.nih.gov/pubmed/33202089 http://dx.doi.org/10.1111/cts.12930

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