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Effect of Crohn’s Disease on Villous Length and CYP3A4 Expression in the Pediatric Small Intestine
Changes in absorptive capacity and first‐pass metabolism in the small intestine affect oral drug bioavailability. Characterization of such changes as a consequence of inflammation is important for developing physiologically‐based pharmacokinetic (PBPK) models for inflammatory bowel disease. We sough...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993283/ https://www.ncbi.nlm.nih.gov/pubmed/33278326 http://dx.doi.org/10.1111/cts.12938 |