Role of ACE2 genetic polymorphisms in susceptibility to SARS-CoV-2 among highly exposed but non infected healthcare workers

We aim to evaluate the role of single-nucleotide polymorphisms of the angiotensin-converting enzyme 2 in susceptibility to SARS-CoV-2 infection. We included 28 uninfected but highly exposed healthcare workers and 39 hospitalized patients with COVID-19. Thirty-five SNPs were rationally selected. Two...

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Detalles Bibliográficos
Autores principales: Martínez-Sanz, Javier, Jiménez, Daniel, Martínez-Campelo, Laura, Cruz, Raquel, Vizcarra, Pilar, Sánchez-Conde, Matilde, Ron, Raquel, Rodríguez, Mario, Herrera, Sabina, Moreno, Santiago, López-Huertas, María Rosa, Serrano-Villar, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993370/
https://www.ncbi.nlm.nih.gov/pubmed/33704002
http://dx.doi.org/10.1080/22221751.2021.1902755
Descripción
Sumario:We aim to evaluate the role of single-nucleotide polymorphisms of the angiotensin-converting enzyme 2 in susceptibility to SARS-CoV-2 infection. We included 28 uninfected but highly exposed healthcare workers and 39 hospitalized patients with COVID-19. Thirty-five SNPs were rationally selected. Two variants were associated with increased risk of being susceptible to SARS-CoV-2: the minor A allele in the rs2106806 variant (OR 3.75 [95% CI 1.23–11.43]) and the minor T allele in the rs6629110 variant (OR 3.39 [95% CI 1.09–10.56]). Evaluating the role of genetic variants in susceptibility to SARS-CoV-2 infection could help identify more vulnerable individuals and suggest potential drug targets for COVID-19 patients.

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