8-Mercaptoguanine-based inhibitors of Mycobacterium tuberculosis dihydroneopterin aldolase: synthesis, in vitro inhibition and docking studies

The dihydroneopterin aldolase (DHNA, EC 4.1.2.25) activity of FolB protein is required for the conversion of 7,8-dihydroneopterin (DHNP) to 6-hydroxymethyl-7,8-dihydropterin (HP) and glycolaldehyde (GA) in the folate pathway. FolB protein from Mycobacterium tuberculosis (MtFolB) is essential for bac...

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Detalles Bibliográficos
Autores principales: Czeczot, Alexia de Matos, Roth, Candida Deves, Ducati, Rodrigo Gay, Pissinate, Kenia, Rambo, Raoní Scheibler, Timmers, Luís Fernando Saraiva Macedo, Abbadi, Bruno Lopes, Macchi, Fernanda Souza, Pestana, Víctor Zajaczkowski, Basso, Luiz Augusto, Machado, Pablo, Bizarro, Cristiano Valim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993393/
https://www.ncbi.nlm.nih.gov/pubmed/33752554
http://dx.doi.org/10.1080/14756366.2021.1900157

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