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The prevalence and distribution of human papillomavirus among 10,867 Chinese Han women

OBJECTIVE: To assess the prevalence and distribution of HPV genotypes among Chinese Han women, and to explore the risk of high-grade cervical lesions associated with individual hr-HPV genotypes. METHODS: Genotyping and histopathology data from the Chinese Multi-Center Screening Trial (CHIMUST) and i...

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Autores principales: Guo, Chunlei, Du, Hui, Belinson, Jerome L., Wang, Chun, Huang, Xia, Qu, Xinfeng, Wu, Ruifang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993460/
https://www.ncbi.nlm.nih.gov/pubmed/33766103
http://dx.doi.org/10.1186/s13027-021-00360-9
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author Guo, Chunlei
Du, Hui
Belinson, Jerome L.
Wang, Chun
Huang, Xia
Qu, Xinfeng
Wu, Ruifang
author_facet Guo, Chunlei
Du, Hui
Belinson, Jerome L.
Wang, Chun
Huang, Xia
Qu, Xinfeng
Wu, Ruifang
author_sort Guo, Chunlei
collection PubMed
description OBJECTIVE: To assess the prevalence and distribution of HPV genotypes among Chinese Han women, and to explore the risk of high-grade cervical lesions associated with individual hr-HPV genotypes. METHODS: Genotyping and histopathology data from the Chinese Multi-Center Screening Trial (CHIMUST) and its pilot screening trial, from 6 regions across mainland China, were re-analyzed. The data from physician- and self-collected samples from 10,867 Chinese Han women (ages 30–69) were used to determine the prevalence and distribution of hr-HPV and to explore the risk association between hr-HPV genotypes and precancerous lesions. RESULTS: 9.2% of the study population tested hr-HPV positive in physician-collected sample. The prevalence varied regionally from the lowest in Guangdong (6.3%) to the highest in Inner Mongolia (13.0%). The most prevalent genotypes found were HPV-52 (21.7%), HPV-16 (19.2%), HPV-58 (15.0%), HPV-39 (8.9%), and HPV-51 (8.2%). The overall odds ratios for CIN2+ and CIN3+ for the presence of HPV-16 was 58.6 (95% CI 39.2–87.5) and, 91.6 (95%CI 54.3–154.6), respectively and remained the highest odds ratio for CIN3+ in all 6 regions. CONCLUSION: Geographical variation exists in the prevalence and distribution of hr-HPV in mainland China. HPV-16/52/58 were the most prevalent genotypes, and HPV-16 had the highest risk for high-grade cervical lesions. TRIAL REGISTRATION: CHIMUST, Registration number: ChiCTR-EOC-16008456. Registered 11 May 2016.
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spelling pubmed-79934602021-03-26 The prevalence and distribution of human papillomavirus among 10,867 Chinese Han women Guo, Chunlei Du, Hui Belinson, Jerome L. Wang, Chun Huang, Xia Qu, Xinfeng Wu, Ruifang Infect Agent Cancer Research Article OBJECTIVE: To assess the prevalence and distribution of HPV genotypes among Chinese Han women, and to explore the risk of high-grade cervical lesions associated with individual hr-HPV genotypes. METHODS: Genotyping and histopathology data from the Chinese Multi-Center Screening Trial (CHIMUST) and its pilot screening trial, from 6 regions across mainland China, were re-analyzed. The data from physician- and self-collected samples from 10,867 Chinese Han women (ages 30–69) were used to determine the prevalence and distribution of hr-HPV and to explore the risk association between hr-HPV genotypes and precancerous lesions. RESULTS: 9.2% of the study population tested hr-HPV positive in physician-collected sample. The prevalence varied regionally from the lowest in Guangdong (6.3%) to the highest in Inner Mongolia (13.0%). The most prevalent genotypes found were HPV-52 (21.7%), HPV-16 (19.2%), HPV-58 (15.0%), HPV-39 (8.9%), and HPV-51 (8.2%). The overall odds ratios for CIN2+ and CIN3+ for the presence of HPV-16 was 58.6 (95% CI 39.2–87.5) and, 91.6 (95%CI 54.3–154.6), respectively and remained the highest odds ratio for CIN3+ in all 6 regions. CONCLUSION: Geographical variation exists in the prevalence and distribution of hr-HPV in mainland China. HPV-16/52/58 were the most prevalent genotypes, and HPV-16 had the highest risk for high-grade cervical lesions. TRIAL REGISTRATION: CHIMUST, Registration number: ChiCTR-EOC-16008456. Registered 11 May 2016. BioMed Central 2021-03-25 /pmc/articles/PMC7993460/ /pubmed/33766103 http://dx.doi.org/10.1186/s13027-021-00360-9 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Guo, Chunlei
Du, Hui
Belinson, Jerome L.
Wang, Chun
Huang, Xia
Qu, Xinfeng
Wu, Ruifang
The prevalence and distribution of human papillomavirus among 10,867 Chinese Han women
title The prevalence and distribution of human papillomavirus among 10,867 Chinese Han women
title_full The prevalence and distribution of human papillomavirus among 10,867 Chinese Han women
title_fullStr The prevalence and distribution of human papillomavirus among 10,867 Chinese Han women
title_full_unstemmed The prevalence and distribution of human papillomavirus among 10,867 Chinese Han women
title_short The prevalence and distribution of human papillomavirus among 10,867 Chinese Han women
title_sort prevalence and distribution of human papillomavirus among 10,867 chinese han women
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993460/
https://www.ncbi.nlm.nih.gov/pubmed/33766103
http://dx.doi.org/10.1186/s13027-021-00360-9
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