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Elevated frequencies of CD14(+)HLA-DR(lo/neg) MDSCs in COVID-19 patients
Background: The immune responses, hyper-inflammation or immunosuppression, may be closely related to COVID-19 progression. We aimed to evaluate the changes of frequency of CD14(+)HLA-DR(lo/neg) MDSCs, a population of cells with potent immunosuppressive capacity, in COVID-19 patients. Methods: The le...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993675/ https://www.ncbi.nlm.nih.gov/pubmed/33640878 http://dx.doi.org/10.18632/aging.202571 |
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author | Xue, GuoHui Jiang, Mei Zhao, Rui Le, AiPing Li, JunMing |
author_facet | Xue, GuoHui Jiang, Mei Zhao, Rui Le, AiPing Li, JunMing |
author_sort | Xue, GuoHui |
collection | PubMed |
description | Background: The immune responses, hyper-inflammation or immunosuppression, may be closely related to COVID-19 progression. We aimed to evaluate the changes of frequency of CD14(+)HLA-DR(lo/neg) MDSCs, a population of cells with potent immunosuppressive capacity, in COVID-19 patients. Methods: The levels of CD14(+)HLA-DR(lo/neg) MDSCs were determined by flow cytometry in 27 COVID-19 patients, and their association with clinical characteristics and laboratory data were analyzed. Results: The frequency of CD14(+)HLA-DR(lo/neg) MDSCs was elevated in COVID-19 patients, particularly severe patients. A follow-up comparison revealed a decline of CD14(+)HLA-DR(lo/neg) MDSCs percentages in most patients 1 day after testing negative for SARS-CoV-2 nucleic acid, but the levels of CD14(+)HLA-DR(lo/neg) MDSCs were still greater than 50.0% in 3 ICU patients 4-10 days after negative SARS-CoV-2 results. Elevated frequency of CD14(+)HLA-DR(lo/neg) MDSCs was positively correlated with oropharyngeal viral loads and length of hospital stay, while negatively correlated with lymphocyte counts and serum albumin. Moreover, strong correlations were observed between the frequency of CD14(+)HLA-DR(lo/neg) MDSCs and T cell subsets, NK cell counts, and B cell percentages. The frequency of CD14(+)HLA-DR(lo/neg) MDSCs could be used as a predictor of COVID-19 severity. Conclusions: A high frequency of CD14(+)HLA-DR(lo/neg) MDSCs, especially in severe patients, may indicate an immunoparalysis status and could be a predictor of disease severity and prognosis. |
format | Online Article Text |
id | pubmed-7993675 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-79936752021-04-06 Elevated frequencies of CD14(+)HLA-DR(lo/neg) MDSCs in COVID-19 patients Xue, GuoHui Jiang, Mei Zhao, Rui Le, AiPing Li, JunMing Aging (Albany NY) Research Paper Background: The immune responses, hyper-inflammation or immunosuppression, may be closely related to COVID-19 progression. We aimed to evaluate the changes of frequency of CD14(+)HLA-DR(lo/neg) MDSCs, a population of cells with potent immunosuppressive capacity, in COVID-19 patients. Methods: The levels of CD14(+)HLA-DR(lo/neg) MDSCs were determined by flow cytometry in 27 COVID-19 patients, and their association with clinical characteristics and laboratory data were analyzed. Results: The frequency of CD14(+)HLA-DR(lo/neg) MDSCs was elevated in COVID-19 patients, particularly severe patients. A follow-up comparison revealed a decline of CD14(+)HLA-DR(lo/neg) MDSCs percentages in most patients 1 day after testing negative for SARS-CoV-2 nucleic acid, but the levels of CD14(+)HLA-DR(lo/neg) MDSCs were still greater than 50.0% in 3 ICU patients 4-10 days after negative SARS-CoV-2 results. Elevated frequency of CD14(+)HLA-DR(lo/neg) MDSCs was positively correlated with oropharyngeal viral loads and length of hospital stay, while negatively correlated with lymphocyte counts and serum albumin. Moreover, strong correlations were observed between the frequency of CD14(+)HLA-DR(lo/neg) MDSCs and T cell subsets, NK cell counts, and B cell percentages. The frequency of CD14(+)HLA-DR(lo/neg) MDSCs could be used as a predictor of COVID-19 severity. Conclusions: A high frequency of CD14(+)HLA-DR(lo/neg) MDSCs, especially in severe patients, may indicate an immunoparalysis status and could be a predictor of disease severity and prognosis. Impact Journals 2021-02-26 /pmc/articles/PMC7993675/ /pubmed/33640878 http://dx.doi.org/10.18632/aging.202571 Text en Copyright: © 2021 Xue et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Xue, GuoHui Jiang, Mei Zhao, Rui Le, AiPing Li, JunMing Elevated frequencies of CD14(+)HLA-DR(lo/neg) MDSCs in COVID-19 patients |
title | Elevated frequencies of CD14(+)HLA-DR(lo/neg) MDSCs in COVID-19 patients |
title_full | Elevated frequencies of CD14(+)HLA-DR(lo/neg) MDSCs in COVID-19 patients |
title_fullStr | Elevated frequencies of CD14(+)HLA-DR(lo/neg) MDSCs in COVID-19 patients |
title_full_unstemmed | Elevated frequencies of CD14(+)HLA-DR(lo/neg) MDSCs in COVID-19 patients |
title_short | Elevated frequencies of CD14(+)HLA-DR(lo/neg) MDSCs in COVID-19 patients |
title_sort | elevated frequencies of cd14(+)hla-dr(lo/neg) mdscs in covid-19 patients |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993675/ https://www.ncbi.nlm.nih.gov/pubmed/33640878 http://dx.doi.org/10.18632/aging.202571 |
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