Cargando…

Lupeol ameliorates LPS/D-GalN induced acute hepatic damage by suppressing inflammation and oxidative stress through TGFβ1-Nrf2 signal pathway

Acute hepatic damage is a severe condition characterized by inflammation and oxidative stress, which is a serious threat to people's life and health. But there are few effective treatments for acute liver injury. Therefore, safe and effective therapeutic approaches for preventing acute liver da...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Sha, Mo, Chan, Zeng, Ting, Lai, Yuqi, Zhou, Chuying, Xie, Shunwen, Chen, Limei, Wang, Yuhua, Chen, Yuyao, Huang, Shaohui, Gao, Lei, Lv, Zhiping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993700/ https://www.ncbi.nlm.nih.gov/pubmed/33707345 http://dx.doi.org/10.18632/aging.202409

Ejemplares similares

Hepatic TGFβr1 Deficiency Attenuates Lipopolysaccharide/D-Galactosamine–Induced Acute Liver Failure Through Inhibiting GSK3β–Nrf2–Mediated Hepatocyte Apoptosis and Ferroptosis
por: Huang, Sha, et al.
Publicado: (2022)

Deletion of caveolin‐1 attenuates LPS/GalN‐induced acute liver injury in mice
por: Tsai, Tsung‐Huang, et al.
Publicado: (2018)

BML-111 Protected LPS/D-GalN-Induced Acute Liver Injury in Rats
por: Yan, Dan, et al.
Publicado: (2016)

Complement and the Alternative Pathway Play an Important Role in LPS/D-GalN-Induced Fulminant Hepatic Failure
por: Sun, Shihui, et al.
Publicado: (2011)

P-Hydroxyacetophenone Ameliorates Alcohol-Induced Steatosis and Oxidative Stress via the NF-κB Signaling Pathway in Zebrafish and Hepatocytes
por: Huang, Sha, et al.
Publicado: (2020)

Inhibition of Glycogen Synthase Kinase 3β Ameliorates D-GalN/LPS-Induced Liver Injury by Reducing Endoplasmic Reticulum Stress-Triggered Apoptosis
por: Chen, Liyan, et al.
Publicado: (2012)

Distinct effects of different doses of kaempferol on D-GalN/LPS-induced ALF depend on the autophagy pathway
por: Tian, Yuan, et al.
Publicado: (2021)

Mangiferin Attenuates LPS/D-GalN-Induced Acute Liver Injury by Promoting HO-1 in Kupffer Cells
por: Yang, Sen, et al.
Publicado: (2020)

Oxidative stress promotes d-GalN/LPS-induced acute hepatotoxicity by increasing glycogen synthase kinase 3β activity
por: Wei, Linlin, et al.
Publicado: (2014)

Exacerbated LPS/GalN-Induced Liver Injury in the Stress-Sensitive Wistar Kyoto Rat Is Associated with Changes in the Endocannabinoid System
por: Killilea, Marykate, et al.
Publicado: (2020)

Protective Effects of p-CA Against Acute Liver Damage Induced by LPS/D-GalN in Wistar Albino Rats
por: Mehdi, Seerat, et al.
Publicado: (2022)

Identification of key immune-related genes associated with LPS/D-GalN-induced acute liver failure in mice based on transcriptome sequencing
por: Chen, Ling, et al.
Publicado: (2023)

Intraportally delivered stem cell spheroids localize in the liver and protect hepatocytes against GalN/LPS-induced fulminant hepatic toxicity
por: Regmi, Shobha, et al.
Publicado: (2019)

Prevention of D-GalN/LPS-induced ALI by 18β-glycyrrhetinic acid through PXR-mediated inhibition of autophagy degradation
por: Wu, Shouyan, et al.
Publicado: (2021)

Domino hepatocyte transplantation using explanted human livers with metabolic defects attenuates D-GalN/LPS-induced acute liver failure
por: Zhou, Guang-Peng, et al.
Publicado: (2022)

Swertia cincta Burkill alleviates LPS/D-GalN-induced acute liver failure by modulating apoptosis and oxidative stress signaling pathways
por: Wu, Xinyan, et al.
Publicado: (2023)

Apolipoprotein A5 alleviates LPS/d-GalN-induced fulminant liver failure in mice by inhibiting TLR4-mediated NF-κB pathway
por: Tao, Ya-Chao, et al.
Publicado: (2019)

Ginsenoside Rb1 Alleviates Alcohol-Induced Liver Injury by Inhibiting Steatosis, Oxidative Stress, and Inflammation
por: Lai, Yuqi, et al.
Publicado: (2021)

Anti-inflammation and anti-apoptosis effects of growth arrest-specific protein 6 in acute liver injury induced by LPS/D-GalN in mice
por: Wang, Qian, et al.
Publicado: (2020)

The effects of rhein on D-GalN/LPS-induced acute liver injury in mice: Results from gut microbiome-metabolomics and host transcriptome analysis
por: Liu, Shuhui, et al.
Publicado: (2022)

Inhibition of Sophocarpine on Poly I: C/D-GalN-Induced Immunological Liver Injury in Mice
por: Huang, Yin-Qiu, et al.
Publicado: (2016)

Microbial metabolites indole derivatives sensitize mice to D-GalN/LPS induced-acute liver failure via the Tlr2/NF-κB pathway
por: Zhou, Ziyuan, et al.
Publicado: (2023)

Protective Role of 4-Octyl Itaconate in Murine LPS/D-GalN-Induced Acute Liver Failure via Inhibiting Inflammation, Oxidative Stress, and Apoptosis
por: Li, Ruidong, et al.
Publicado: (2021)

UMSCs Attenuate LPS/D-GalN-induced Acute Liver Failure in Mice by Down-regulating the MyD88/NF-κB Pathway
por: Liao, Hailing, et al.
Publicado: (2021)

Apoptotic Response through a High Mobility Box 1 Protein-Dependent Mechanism in LPS/GalN-Induced Mouse Liver Failure and Glycyrrhizin-Mediated Inhibition
por: Kuroda, Noriyuki, et al.
Publicado: (2014)

Hepatocyte-Conditional Knockout of Phosphatidylethanolamine Binding Protein 4 Aggravated LPS/D-GalN-Induced Acute Liver Injury via the TLR4/NF-κB Pathway
por: Qu, Xiao-qin, et al.
Publicado: (2022)

Ginsenoside Rb1 Reduces D-GalN/LPS-induced Acute Liver Injury by Regulating TLR4/NF-κB Signaling and NLRP3 Inflammasome
por: Liu, Yimei, et al.
Publicado: (2022)

Eriodictyol Alleviated LPS/D-GalN-Induced Acute Liver Injury by Inhibiting Oxidative Stress and Cell Apoptosis via PI3K/AKT Signaling Pathway
por: Zheng, Xiaomei, et al.
Publicado: (2023)

Luteolin and luteolin-7-O-glucoside protect against acute liver injury through regulation of inflammatory mediators and antioxidative enzymes in GalN/LPS-induced hepatitic ICR mice
por: Park, Chung Mu, et al.
Publicado: (2019)

Deer antler based active ingredients have protective effects on LPS/d-GalN-induced acute liver injury in mice through MAPK and NF-κB signalling pathways
por: He, Guixiang, et al.
Publicado: (2022)

Indoleamine 2,3-dioxygenase 1 limits hepatic inflammatory cells recruitment and promotes bile duct ligation-induced liver fibrosis
por: Mo, Chan, et al.
Publicado: (2021)

CRACC-CRACC Interaction between Kupffer and NK Cells Contributes to Poly I:C/D-GalN Induced Hepatitis
por: Li, Yangxi, et al.
Publicado: (2013)

Chromatin Regulator SRG3 Overexpression Protects against LPS/D-GalN-Induced Sepsis by Increasing IL10-Producing Macrophages and Decreasing IFNγ-Producing NK Cells in the Liver
por: Lee, Sung Won, et al.
Publicado: (2021)

Mixed Electronic-Ionic Conductivity and Stability of Spark Plasma Sintered Graphene-Augmented Alumina Nanofibres Doped Yttria Stabilized Zirconia GAlN/YSZ Composites
por: Kurapova, Olga, et al.
Publicado: (2023)

Lupeol Accumulation Correlates with Auxin in the Epidermis of Castor
por: Li, Donghai, et al.
Publicado: (2021)

Protective effects of Schisandrin B against D-GalN-induced cell apoptosis in human hepatocyte (L02) cells via modulating Bcl-2 and Bax
por: Hu, Yanwu, et al.
Publicado: (2021)

Screening of Filamentous Fungi to Identify Biocatalysts for Lupeol Biotransformation
por: de Carvalho, Tatiane C., et al.
Publicado: (2010)

Molecular docking analysis of lupeol with different cancer targets
por: Gunasekaran, Mahalakshmi, et al.
Publicado: (2022)

Salmonella Enteritidis GalE Protein Inhibits LPS-Induced NLRP3 Inflammasome Activation
por: Huang, Tingting, et al.
Publicado: (2022)

New lupeol esters as active substances in the treatment of skin damage
por: Malinowska, Magdalena, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_f6bsjq9kj0cq8vm5jubpkv8s1q