Maf1 suppression of ATF5-dependent mitochondrial unfolded protein response contributes to rapamycin-induced radio-sensitivity in lung cancer cell line A549

mTOR is well known to promote tumor growth but its roles in enhancing chemotherapy and radiotherapy have not been well studied. mTOR inhibition by rapamycin can sensitize cancer cells to radiotherapy. Here we show that Maf1 is required for rapamycin to increase radio-sensitivity in A549 lung cancer...

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Detalles Bibliográficos
Autores principales: Lai, Chen, Zhang, Jing, Tan, Zhaohua, Shen, Liang F., Zhou, Rong R., Zhang, Ying Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993702/
https://www.ncbi.nlm.nih.gov/pubmed/33640883
http://dx.doi.org/10.18632/aging.202584

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