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The serum galectin-3 levels are associated with the severity and prognosis of ischemic stroke
Galectin-3, a microglia/macrophage-derived inflammatory mediator, plays a role in the stroke progression. In this single-center prospective study, we included 288 consecutive patients with a first-ever acute ischemic stroke to assess the association between galectin-3 serum level and clinical severi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993705/ https://www.ncbi.nlm.nih.gov/pubmed/33686023 http://dx.doi.org/10.18632/aging.202610 |
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author | Zhuang, Jia-Jun Zhou, Li Zheng, Yan-Hua Ding, Yan-Sheng |
author_facet | Zhuang, Jia-Jun Zhou, Li Zheng, Yan-Hua Ding, Yan-Sheng |
author_sort | Zhuang, Jia-Jun |
collection | PubMed |
description | Galectin-3, a microglia/macrophage-derived inflammatory mediator, plays a role in the stroke progression. In this single-center prospective study, we included 288 consecutive patients with a first-ever acute ischemic stroke to assess the association between galectin-3 serum level and clinical severity at admission and outcome at discharge by univariate and multivariate logistic regression. The results were presented as odds ratios (OR) and 95% confidence intervals (CI). Patients with high severity and poor outcomes had higher serum levels of galectin-3 (P<0.001 and P<0.001). Multivariate analysis suggested that a galectin-3 serum level in the highest quartile (The lowest three quartiles[Q1-3] as the reference) was associated with poor functional outcome (OR, 3.15; 95% CI, 2.44–3.87). The AUC (standard error) for the NIHSS and the combined model were 0.764 (0.031) and 0.823 (0.027), corresponding to a difference of 0.059 (0.004). This study shows that higher serum levels of galectin-3 are associated with stroke severity at admission and stroke prognosis at discharge in ischemic stroke. |
format | Online Article Text |
id | pubmed-7993705 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-79937052021-04-06 The serum galectin-3 levels are associated with the severity and prognosis of ischemic stroke Zhuang, Jia-Jun Zhou, Li Zheng, Yan-Hua Ding, Yan-Sheng Aging (Albany NY) Research Paper Galectin-3, a microglia/macrophage-derived inflammatory mediator, plays a role in the stroke progression. In this single-center prospective study, we included 288 consecutive patients with a first-ever acute ischemic stroke to assess the association between galectin-3 serum level and clinical severity at admission and outcome at discharge by univariate and multivariate logistic regression. The results were presented as odds ratios (OR) and 95% confidence intervals (CI). Patients with high severity and poor outcomes had higher serum levels of galectin-3 (P<0.001 and P<0.001). Multivariate analysis suggested that a galectin-3 serum level in the highest quartile (The lowest three quartiles[Q1-3] as the reference) was associated with poor functional outcome (OR, 3.15; 95% CI, 2.44–3.87). The AUC (standard error) for the NIHSS and the combined model were 0.764 (0.031) and 0.823 (0.027), corresponding to a difference of 0.059 (0.004). This study shows that higher serum levels of galectin-3 are associated with stroke severity at admission and stroke prognosis at discharge in ischemic stroke. Impact Journals 2021-03-03 /pmc/articles/PMC7993705/ /pubmed/33686023 http://dx.doi.org/10.18632/aging.202610 Text en Copyright: © 2021 Zhuang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Zhuang, Jia-Jun Zhou, Li Zheng, Yan-Hua Ding, Yan-Sheng The serum galectin-3 levels are associated with the severity and prognosis of ischemic stroke |
title | The serum galectin-3 levels are associated with the severity and prognosis of ischemic stroke |
title_full | The serum galectin-3 levels are associated with the severity and prognosis of ischemic stroke |
title_fullStr | The serum galectin-3 levels are associated with the severity and prognosis of ischemic stroke |
title_full_unstemmed | The serum galectin-3 levels are associated with the severity and prognosis of ischemic stroke |
title_short | The serum galectin-3 levels are associated with the severity and prognosis of ischemic stroke |
title_sort | serum galectin-3 levels are associated with the severity and prognosis of ischemic stroke |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993705/ https://www.ncbi.nlm.nih.gov/pubmed/33686023 http://dx.doi.org/10.18632/aging.202610 |
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