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Calorie restriction prevents age-related changes in the intestinal microbiota

The effect of calorie restriction (CR) on the microbiome, fecal metabolome, and colon transcriptome of adult and old male mice was compared. Life-long CR increased microbial diversity and the Bacteroidetes/Firmicutes ratio and prevented the age-related changes in the microbiota, shifting it to a you...

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Autores principales: Kurup, Kavitha, Matyi, Stephanie, Giles, Cory B., Wren, Jonathan D., Jones, Kenneth, Ericsson, Aaron, Raftery, Daniel, Wang, Lu, Promislow, Daniel, Richardson, Arlan, Unnikrishnan, Archana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993711/
https://www.ncbi.nlm.nih.gov/pubmed/33744869
http://dx.doi.org/10.18632/aging.202753
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author Kurup, Kavitha
Matyi, Stephanie
Giles, Cory B.
Wren, Jonathan D.
Jones, Kenneth
Ericsson, Aaron
Raftery, Daniel
Wang, Lu
Promislow, Daniel
Richardson, Arlan
Unnikrishnan, Archana
author_facet Kurup, Kavitha
Matyi, Stephanie
Giles, Cory B.
Wren, Jonathan D.
Jones, Kenneth
Ericsson, Aaron
Raftery, Daniel
Wang, Lu
Promislow, Daniel
Richardson, Arlan
Unnikrishnan, Archana
author_sort Kurup, Kavitha
collection PubMed
description The effect of calorie restriction (CR) on the microbiome, fecal metabolome, and colon transcriptome of adult and old male mice was compared. Life-long CR increased microbial diversity and the Bacteroidetes/Firmicutes ratio and prevented the age-related changes in the microbiota, shifting it to a younger microbial and fecal metabolite profile in both C57BL/6JN and B6D2F1 mice. Old mice fed CR were enriched in the Rikenellaceae, S24-7 and Bacteroides families. The changes in the microbiome that occur with age and CR were initiated in the cecum and further modified in the colon. Short-term CR in adult mice had a minor effect on the microbiome but a major effect on the transcriptome of the colon mucosa. These data suggest that CR has a major impact on the physiological status of the gastrointestinal system, maintaining it in a more youthful state, which in turn could result in a more diverse and youthful microbiome.
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spelling pubmed-79937112021-04-06 Calorie restriction prevents age-related changes in the intestinal microbiota Kurup, Kavitha Matyi, Stephanie Giles, Cory B. Wren, Jonathan D. Jones, Kenneth Ericsson, Aaron Raftery, Daniel Wang, Lu Promislow, Daniel Richardson, Arlan Unnikrishnan, Archana Aging (Albany NY) Research Paper The effect of calorie restriction (CR) on the microbiome, fecal metabolome, and colon transcriptome of adult and old male mice was compared. Life-long CR increased microbial diversity and the Bacteroidetes/Firmicutes ratio and prevented the age-related changes in the microbiota, shifting it to a younger microbial and fecal metabolite profile in both C57BL/6JN and B6D2F1 mice. Old mice fed CR were enriched in the Rikenellaceae, S24-7 and Bacteroides families. The changes in the microbiome that occur with age and CR were initiated in the cecum and further modified in the colon. Short-term CR in adult mice had a minor effect on the microbiome but a major effect on the transcriptome of the colon mucosa. These data suggest that CR has a major impact on the physiological status of the gastrointestinal system, maintaining it in a more youthful state, which in turn could result in a more diverse and youthful microbiome. Impact Journals 2021-03-10 /pmc/articles/PMC7993711/ /pubmed/33744869 http://dx.doi.org/10.18632/aging.202753 Text en Copyright: © 2021 Kurup et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Kurup, Kavitha
Matyi, Stephanie
Giles, Cory B.
Wren, Jonathan D.
Jones, Kenneth
Ericsson, Aaron
Raftery, Daniel
Wang, Lu
Promislow, Daniel
Richardson, Arlan
Unnikrishnan, Archana
Calorie restriction prevents age-related changes in the intestinal microbiota
title Calorie restriction prevents age-related changes in the intestinal microbiota
title_full Calorie restriction prevents age-related changes in the intestinal microbiota
title_fullStr Calorie restriction prevents age-related changes in the intestinal microbiota
title_full_unstemmed Calorie restriction prevents age-related changes in the intestinal microbiota
title_short Calorie restriction prevents age-related changes in the intestinal microbiota
title_sort calorie restriction prevents age-related changes in the intestinal microbiota
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993711/
https://www.ncbi.nlm.nih.gov/pubmed/33744869
http://dx.doi.org/10.18632/aging.202753
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