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Association between body mass index and risk of cardiovascular disease-specific mortality among adults with hypertension in Shanghai, China
The aim of our study was to examine the association between body mass index (BMI) and the risk of cardiovascular disease (CVD)-specific mortality among Chinese adults with hypertension by sex. This study included 212,394 adult hypertensive patients aged 20–85 years registered in the records of Minha...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993713/ https://www.ncbi.nlm.nih.gov/pubmed/33621195 http://dx.doi.org/10.18632/aging.202543 |
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author | Hu, Jing Xu, Huilin Zhu, Jingjing Zhang, Jinling Li, Jun Chen, Linli Liu, Xiaohua Qin, Guoyou |
author_facet | Hu, Jing Xu, Huilin Zhu, Jingjing Zhang, Jinling Li, Jun Chen, Linli Liu, Xiaohua Qin, Guoyou |
author_sort | Hu, Jing |
collection | PubMed |
description | The aim of our study was to examine the association between body mass index (BMI) and the risk of cardiovascular disease (CVD)-specific mortality among Chinese adults with hypertension by sex. This study included 212,394 adult hypertensive patients aged 20–85 years registered in the records of Minhang District during 2007–2018. Cox proportional hazards regression was performed to evaluate the association between BMI and CVD-specific mortality among Chinese adults with hypertension. There were 14,029 deaths over an average of 8.24 years (range, 0.19–11.96 years). The multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) across BMI categories (< 18.5 kg/m(2), 18.5–24.9 kg/m(2) [reference group], 25.0–29.9 kg/m(2), and ≥ 30 kg/m(2)) for CVD-specific mortality were 1.37 (1.22–1.53), 1.00 (reference), 0.95 (0.90–1.01), and 1.21 (1.04–1.40) in males, and 1.44 (1.31–1.59), 1.00 (reference), 0.96 (0.91–1.01), and 1.04 (0.92–1.17) in females. A U-shaped relationship was observed between BMI and CVD-specific mortality (overall association P< 0.001; non-linearity P< 0.001). This association was attenuated in old age. This study revealed a U-shaped relationship between BMI and CVD-specific mortality among hypertensive men and women. In older people, overweight and obesity are potential factors that reduce the risk of CVD death. |
format | Online Article Text |
id | pubmed-7993713 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-79937132021-04-06 Association between body mass index and risk of cardiovascular disease-specific mortality among adults with hypertension in Shanghai, China Hu, Jing Xu, Huilin Zhu, Jingjing Zhang, Jinling Li, Jun Chen, Linli Liu, Xiaohua Qin, Guoyou Aging (Albany NY) Research Paper The aim of our study was to examine the association between body mass index (BMI) and the risk of cardiovascular disease (CVD)-specific mortality among Chinese adults with hypertension by sex. This study included 212,394 adult hypertensive patients aged 20–85 years registered in the records of Minhang District during 2007–2018. Cox proportional hazards regression was performed to evaluate the association between BMI and CVD-specific mortality among Chinese adults with hypertension. There were 14,029 deaths over an average of 8.24 years (range, 0.19–11.96 years). The multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) across BMI categories (< 18.5 kg/m(2), 18.5–24.9 kg/m(2) [reference group], 25.0–29.9 kg/m(2), and ≥ 30 kg/m(2)) for CVD-specific mortality were 1.37 (1.22–1.53), 1.00 (reference), 0.95 (0.90–1.01), and 1.21 (1.04–1.40) in males, and 1.44 (1.31–1.59), 1.00 (reference), 0.96 (0.91–1.01), and 1.04 (0.92–1.17) in females. A U-shaped relationship was observed between BMI and CVD-specific mortality (overall association P< 0.001; non-linearity P< 0.001). This association was attenuated in old age. This study revealed a U-shaped relationship between BMI and CVD-specific mortality among hypertensive men and women. In older people, overweight and obesity are potential factors that reduce the risk of CVD death. Impact Journals 2021-02-17 /pmc/articles/PMC7993713/ /pubmed/33621195 http://dx.doi.org/10.18632/aging.202543 Text en Copyright: © 2021 Hu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Hu, Jing Xu, Huilin Zhu, Jingjing Zhang, Jinling Li, Jun Chen, Linli Liu, Xiaohua Qin, Guoyou Association between body mass index and risk of cardiovascular disease-specific mortality among adults with hypertension in Shanghai, China |
title | Association between body mass index and risk of cardiovascular disease-specific mortality among adults with hypertension in Shanghai, China |
title_full | Association between body mass index and risk of cardiovascular disease-specific mortality among adults with hypertension in Shanghai, China |
title_fullStr | Association between body mass index and risk of cardiovascular disease-specific mortality among adults with hypertension in Shanghai, China |
title_full_unstemmed | Association between body mass index and risk of cardiovascular disease-specific mortality among adults with hypertension in Shanghai, China |
title_short | Association between body mass index and risk of cardiovascular disease-specific mortality among adults with hypertension in Shanghai, China |
title_sort | association between body mass index and risk of cardiovascular disease-specific mortality among adults with hypertension in shanghai, china |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993713/ https://www.ncbi.nlm.nih.gov/pubmed/33621195 http://dx.doi.org/10.18632/aging.202543 |
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