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Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages
Atherosclerosis is a chronic inflammatory disease that commonly affects the elderly and is characterized by vascular damage, macrophage infiltration, and plaque formation. Moreover, it increases the risk of cardiovascular disease. The pathogenesis of atherosclerosis involves an interplay between mac...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993719/ https://www.ncbi.nlm.nih.gov/pubmed/33639613 http://dx.doi.org/10.18632/aging.202566 |
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author | Zheng, Yinghong Kou, Jiayuan Wang, Pengyu Ye, Ting Wang, Zitong Gao, Ziyu Cong, Lin Li, Manman Dong, Bowen Yang, Wei Li, Quanfeng Li, Hong Wang, Rui Yang, Liming |
author_facet | Zheng, Yinghong Kou, Jiayuan Wang, Pengyu Ye, Ting Wang, Zitong Gao, Ziyu Cong, Lin Li, Manman Dong, Bowen Yang, Wei Li, Quanfeng Li, Hong Wang, Rui Yang, Liming |
author_sort | Zheng, Yinghong |
collection | PubMed |
description | Atherosclerosis is a chronic inflammatory disease that commonly affects the elderly and is characterized by vascular damage, macrophage infiltration, and plaque formation. Moreover, it increases the risk of cardiovascular disease. The pathogenesis of atherosclerosis involves an interplay between macrophage autophagy and apoptosis. A recently discovered transcription factor, transcription factor EB (TFEB) is known to activate autophagy in macrophages. Sirtuin deacetylase 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD(+))-dependent histone deacetylase, activates several transcription factors, including TFEB. We studied the effects of berberine on the NAD(+) synthesis pathway and interactions between SIRT1 and TFEB. We also studied the effects of berberine-induced TFEB activation via SIRT1 on autophagy and apoptosis of peritoneal macrophages. We found that berberine promoted autophagy of peritoneal macrophages by activating SIRT1 via the NAD(+) synthesis pathway and, in turn, promoting TFEB nuclear translocation and deacetylation. The functional regulation of SIRT1 and TFEB by berberine could be exploited as a potential therapeutic strategy for atherosclerosis. |
format | Online Article Text |
id | pubmed-7993719 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-79937192021-04-06 Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages Zheng, Yinghong Kou, Jiayuan Wang, Pengyu Ye, Ting Wang, Zitong Gao, Ziyu Cong, Lin Li, Manman Dong, Bowen Yang, Wei Li, Quanfeng Li, Hong Wang, Rui Yang, Liming Aging (Albany NY) Research Paper Atherosclerosis is a chronic inflammatory disease that commonly affects the elderly and is characterized by vascular damage, macrophage infiltration, and plaque formation. Moreover, it increases the risk of cardiovascular disease. The pathogenesis of atherosclerosis involves an interplay between macrophage autophagy and apoptosis. A recently discovered transcription factor, transcription factor EB (TFEB) is known to activate autophagy in macrophages. Sirtuin deacetylase 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD(+))-dependent histone deacetylase, activates several transcription factors, including TFEB. We studied the effects of berberine on the NAD(+) synthesis pathway and interactions between SIRT1 and TFEB. We also studied the effects of berberine-induced TFEB activation via SIRT1 on autophagy and apoptosis of peritoneal macrophages. We found that berberine promoted autophagy of peritoneal macrophages by activating SIRT1 via the NAD(+) synthesis pathway and, in turn, promoting TFEB nuclear translocation and deacetylation. The functional regulation of SIRT1 and TFEB by berberine could be exploited as a potential therapeutic strategy for atherosclerosis. Impact Journals 2021-02-26 /pmc/articles/PMC7993719/ /pubmed/33639613 http://dx.doi.org/10.18632/aging.202566 Text en Copyright: © 2021 Zheng et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Zheng, Yinghong Kou, Jiayuan Wang, Pengyu Ye, Ting Wang, Zitong Gao, Ziyu Cong, Lin Li, Manman Dong, Bowen Yang, Wei Li, Quanfeng Li, Hong Wang, Rui Yang, Liming Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages |
title | Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages |
title_full | Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages |
title_fullStr | Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages |
title_full_unstemmed | Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages |
title_short | Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages |
title_sort | berberine-induced tfeb deacetylation by sirt1 promotes autophagy in peritoneal macrophages |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993719/ https://www.ncbi.nlm.nih.gov/pubmed/33639613 http://dx.doi.org/10.18632/aging.202566 |
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