Ablation of CRBN induces loss of type I collagen and SCH in mouse skin by fibroblast senescence via the p38 MAPK pathway

Cereblon (CRBN) is a substrate receptor of the cullin-RING E3 ubiquitin ligase (CRL) complex that mediates the ubiquitination of several substrates. In this study, CRBN knockout (KO) mice exhibited decreased levels of stratum corneum hydration (SCH) and collagen I expression with an elevated protein...

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Detalles Bibliográficos
Autores principales: Jeon, Seungje, Yoon, Yi-Seul, Kim, Hyoung Kyu, Han, Jin, Lee, Kwang Min, Seol, Jung Eun, Cho, Steve K., Park, Chul-Seung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993720/
https://www.ncbi.nlm.nih.gov/pubmed/33658395
http://dx.doi.org/10.18632/aging.202744

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