Cargando…

Elevated glucose represses lysosomal and mTOR-related genes in renal epithelial cells composed of progenitor CD133(+) cells

Hyperglycemia is one of the major health concern in many parts of the world. One of the serious complications of high glucose levels is diabetic nephropathy. The preliminary microarray study performed on primary human renal tubular epithelial (hRTE) cells exposed to high glucose levels showed a sign...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shrestha, Swojani, Singhal, Sandeep, Sens, Donald A., Somji, Seema, Davis, Bethany A., Guyer, Rachel, Breen, Spencer, Kalonick, Matthew, Garrett, Scott H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993790/ https://www.ncbi.nlm.nih.gov/pubmed/33764985 http://dx.doi.org/10.1371/journal.pone.0248241

Ejemplares similares

Role of HRTPT in kidney proximal epithelial cell regeneration: Integrative differential expression and pathway analyses using microarray and scRNA‐seq
por: Shrestha, Swojani, et al.
Publicado: (2021)

Primary and Immortalized Cultures of Human Proximal Tubule Cells Possess Both Progenitor and Non-Progenitor Cells That Can Impact Experimental Results
por: Shrestha, Swojani, et al.
Publicado: (2023)

Proteasomes Are Critical for Maintenance of CD133+CD24+ Kidney Progenitor Cells
por: Al-Marsoummi, Sarmad, et al.
Publicado: (2023)

Chronic Arsenic Exposure Upregulates the Expression of Basal Transcriptional Factors and Increases Invasiveness of the Non-Muscle Invasive Papillary Bladder Cancer Line RT4
por: Mehus, Aaron A., et al.
Publicado: (2022)

Activation of PPARγ and inhibition of cell proliferation reduces key proteins associated with the basal subtype of bladder cancer in As(3+)-transformed UROtsa cells
por: Mehus, Aaron A., et al.
Publicado: (2020)

Meta-analysis of gene expression profiling reveals novel basal gene signatures in MCF-10A cells transformed with cadmium
por: Blommel, Katrina, et al.
Publicado: (2020)

mTOR and lysosome regulation
por: Puertollano, Rosa
Publicado: (2014)

The mTOR–lysosome axis at the centre of ageing
por: Carosi, Julian M., et al.
Publicado: (2021)

Autophagy termination and lysosome reformation regulated by mTOR
por: Yu, Li, et al.
Publicado: (2010)

Activity-independent targeting of mTOR to lysosomes in primary osteoclasts
por: Wang, Andrew, et al.
Publicado: (2017)

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
por: Settembre, Carmine, et al.
Publicado: (2012)

Pml represses tumour progression through inhibition of mTOR
por: Bernardi, Rosa, et al.
Publicado: (2011)

Zinc, Zinc Transporters, and Cadmium Cytotoxicity in a Cell Culture Model of Human Urothelium
por: Satarug, Soisungwan, et al.
Publicado: (2021)

Arsenite Exposure to Human RPCs (HRTPT) Produces a Reversible Epithelial Mesenchymal Transition (EMT): In-Vitro and In-Silico Study
por: Singhal, Sonalika, et al.
Publicado: (2023)

mTOR controls lysosome tubulation and antigen presentation in macrophages and dendritic cells
por: Saric, Amra, et al.
Publicado: (2016)

Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR
por: Zhang, Xiaoli, et al.
Publicado: (2019)

Ubiquilins Regulate Autophagic Flux through mTOR Signaling and Lysosomal Acidification
por: Şentürk, Mümine, et al.
Publicado: (2019)

Prediction of the Number of Activated Genes in Multiple Independent Cd(+2)- and As(+3)-Induced Malignant Transformations of Human Urothelial Cells (UROtsa)
por: Garrett, Scott H., et al.
Publicado: (2014)

Inhibitory Effect of mTOR Activator MHY1485 on Autophagy: Suppression of Lysosomal Fusion
por: Choi, Yeon Ja, et al.
Publicado: (2012)

The Glucosylceramide Synthase Inhibitor PDMP Causes Lysosomal Lipid Accumulation and mTOR Inactivation
por: Hartwig, Pia, et al.
Publicado: (2021)

Lysosomal lipid switch sensitises to nutrient deprivation and mTOR targeting in pancreatic cancer
por: De Santis, Maria Chiara, et al.
Publicado: (2023)

Transformation of Human Urothelial Cells (UROtsa) by As(3+) and Cd(2+) Induces the Expression of Keratin 6a
por: Somji, Seema, et al.
Publicado: (2008)

Expression of hsp 27, hsp 60, hsc 70, and hsp 70 stress response genes in cultured human urothelial cells (UROtsa) exposed to lethal and sublethal concentrations of sodium arsenite.
por: Rossi, Michael R, et al.
Publicado: (2002)

Correction: Inhibitory Effect of mTOR Activator MHY1485 on Autophagy: Suppression of Lysosomal Fusion
por: Choi, Yeon Ja, et al.
Publicado: (2013)

Loss of CLN7 results in depletion of soluble lysosomal proteins and impaired mTOR reactivation
por: Danyukova, Tatyana, et al.
Publicado: (2018)

mTOR hyperactivity mediates lysosomal dysfunction in Gaucher's disease iPSC-neuronal cells
por: Brown, Robert A., et al.
Publicado: (2019)

Stress granules and mTOR are regulated by membrane atg8ylation during lysosomal damage
por: Jia, Jingyue, et al.
Publicado: (2022)

Cadherin Expression, Vectorial Active Transport, and Metallothionein Isoform 3 Mediated EMT/MET Responses in Cultured Primary and Immortalized Human Proximal Tubule Cells
por: Slusser, Andrea, et al.
Publicado: (2015)

The unique C- and N-terminal sequences of Metallothionein isoform 3 mediate growth inhibition and Vectorial active transport in MCF-7 cells
por: Voels, Brent, et al.
Publicado: (2017)

Heat shock protein 27 expression in human proximal tubule cells exposed to lethal and sublethal concentrations of CdCl2.
por: Somji, S, et al.
Publicado: (1999)

Expression of the constitutive and inducible forms of heat shock protein 70 in human proximal tubule cells exposed to heat, sodium arsenite, and CdCl(2).
por: Somji, S, et al.
Publicado: (1999)

Differential expression of human metallothionein isoform I mRNA in human proximal tubule cells exposed to metals.
por: Garrett, S H, et al.
Publicado: (1998)

Transient mTOR Inhibition Facilitates Continuous Growth of Liver Tumors by Modulating the Maintenance of CD133+ Cell Populations
por: Yang, Zhaojuan, et al.
Publicado: (2011)

Asteltoxin inhibits extracellular vesicle production through AMPK/mTOR-mediated activation of lysosome function
por: Mitani, Fumie, et al.
Publicado: (2022)

Lysosomal TMEM9‐LAMTOR4‐controlled mTOR signaling integrity is required for mammary tumorigenesis
por: Zhang, Shengzhe, et al.
Publicado: (2022)

Carboxy Terminal Tail of Polycystin-1 Regulates Localization of TSC2 to Repress mTOR
por: Dere, Ruhee, et al.
Publicado: (2010)

Short and long term gene expression variation and networking in human proximal tubule cells when exposed to cadmium
por: Garrett, Scott H, et al.
Publicado: (2013)

Exposure of human proximal tubule cells to cd2+, zn2+, and Cu2+ induces metallothionein protein accumulation but not metallothionein isoform 2 mRNA.
por: Garrett, S H, et al.
Publicado: (1998)

Differences in the epigenetic regulation of MT-3 gene expression between parental and Cd(+2 )or As(+3 )transformed human urothelial cells
por: Somji, Seema, et al.
Publicado: (2011)

mTOR Pathway and mTOR Inhibitors in Head and Neck Cancer
por: Gao, Wei, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_puak4lrt92ne6fo69vrqrhsn8k