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SARS-COV-2 comorbidity network and outcome in hospitalized patients in Crema, Italy

We report onset, course, correlations with comorbidities, and diagnostic accuracy of nasopharyngeal swab in 539 individuals suspected to carry SARS-COV-2 admitted to the hospital of Crema, Italy. All individuals underwent clinical and laboratory exams, SARS-COV-2 reverse transcriptase-polymerase cha...

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Autores principales: Gili, Tommaso, Benelli, Giampaolo, Buscarini, Elisabetta, Canetta, Ciro, La Piana, Giuseppe, Merli, Guido, Scartabellati, Alessandro, Viganò, Giovanni, Sfogliarini, Roberto, Melilli, Giovanni, Assandri, Roberto, Cazzato, Daniele, Rossi, Davide Sebastiano, Usai, Susanna, Caldarelli, Guido, Tramacere, Irene, Pellegata, Germano, Lauria, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993836/
https://www.ncbi.nlm.nih.gov/pubmed/33765013
http://dx.doi.org/10.1371/journal.pone.0248498
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author Gili, Tommaso
Benelli, Giampaolo
Buscarini, Elisabetta
Canetta, Ciro
La Piana, Giuseppe
Merli, Guido
Scartabellati, Alessandro
Viganò, Giovanni
Sfogliarini, Roberto
Melilli, Giovanni
Assandri, Roberto
Cazzato, Daniele
Rossi, Davide Sebastiano
Usai, Susanna
Caldarelli, Guido
Tramacere, Irene
Pellegata, Germano
Lauria, Giuseppe
author_facet Gili, Tommaso
Benelli, Giampaolo
Buscarini, Elisabetta
Canetta, Ciro
La Piana, Giuseppe
Merli, Guido
Scartabellati, Alessandro
Viganò, Giovanni
Sfogliarini, Roberto
Melilli, Giovanni
Assandri, Roberto
Cazzato, Daniele
Rossi, Davide Sebastiano
Usai, Susanna
Caldarelli, Guido
Tramacere, Irene
Pellegata, Germano
Lauria, Giuseppe
author_sort Gili, Tommaso
collection PubMed
description We report onset, course, correlations with comorbidities, and diagnostic accuracy of nasopharyngeal swab in 539 individuals suspected to carry SARS-COV-2 admitted to the hospital of Crema, Italy. All individuals underwent clinical and laboratory exams, SARS-COV-2 reverse transcriptase-polymerase chain reaction on nasopharyngeal swab, and chest X-ray and/or computed tomography (CT). Data on onset, course, comorbidities, number of drugs including angiotensin converting enzyme (ACE) inhibitors and angiotensin-II-receptor antagonists (sartans), follow-up swab, pharmacological treatments, non-invasive respiratory support, ICU admission, and deaths were recorded. Among 411 SARS-COV-2 patients (67.7% males) median age was 70.8 years (range 5–99). Chest CT was performed in 317 (77.2%) and showed interstitial pneumonia in 304 (96%). Fatality rate was 17.5% (74% males), with 6.6% in 60–69 years old, 21.1% in 70–79 years old, 38.8% in 80–89 years old, and 83.3% above 90 years. No death occurred below 60 years. Non-invasive respiratory support rate was 27.2% and ICU admission 6.8%. Charlson comorbidity index and high C-reactive protein at admission were significantly associated with death. Use of ACE inhibitors or sartans was not associated with outcomes. Among 128 swab negative patients at admission (63.3% males) median age was 67.7 years (range 1–98). Chest CT was performed in 87 (68%) and showed interstitial pneumonia in 76 (87.3%). Follow-up swab turned positive in 13 of 32 patients. Using chest CT at admission as gold standard on the entire study population of 539 patients, nasopharyngeal swab had 80% accuracy. Comorbidity network analysis revealed a more homogenous distribution 60–40 aged SARS-COV-2 patients across diseases and a crucial different interplay of diseases in the networks of deceased and survived patients. SARS-CoV-2 caused high mortality among patients older than 60 years and correlated with pre-existing multiorgan impairment.
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spelling pubmed-79938362021-04-05 SARS-COV-2 comorbidity network and outcome in hospitalized patients in Crema, Italy Gili, Tommaso Benelli, Giampaolo Buscarini, Elisabetta Canetta, Ciro La Piana, Giuseppe Merli, Guido Scartabellati, Alessandro Viganò, Giovanni Sfogliarini, Roberto Melilli, Giovanni Assandri, Roberto Cazzato, Daniele Rossi, Davide Sebastiano Usai, Susanna Caldarelli, Guido Tramacere, Irene Pellegata, Germano Lauria, Giuseppe PLoS One Research Article We report onset, course, correlations with comorbidities, and diagnostic accuracy of nasopharyngeal swab in 539 individuals suspected to carry SARS-COV-2 admitted to the hospital of Crema, Italy. All individuals underwent clinical and laboratory exams, SARS-COV-2 reverse transcriptase-polymerase chain reaction on nasopharyngeal swab, and chest X-ray and/or computed tomography (CT). Data on onset, course, comorbidities, number of drugs including angiotensin converting enzyme (ACE) inhibitors and angiotensin-II-receptor antagonists (sartans), follow-up swab, pharmacological treatments, non-invasive respiratory support, ICU admission, and deaths were recorded. Among 411 SARS-COV-2 patients (67.7% males) median age was 70.8 years (range 5–99). Chest CT was performed in 317 (77.2%) and showed interstitial pneumonia in 304 (96%). Fatality rate was 17.5% (74% males), with 6.6% in 60–69 years old, 21.1% in 70–79 years old, 38.8% in 80–89 years old, and 83.3% above 90 years. No death occurred below 60 years. Non-invasive respiratory support rate was 27.2% and ICU admission 6.8%. Charlson comorbidity index and high C-reactive protein at admission were significantly associated with death. Use of ACE inhibitors or sartans was not associated with outcomes. Among 128 swab negative patients at admission (63.3% males) median age was 67.7 years (range 1–98). Chest CT was performed in 87 (68%) and showed interstitial pneumonia in 76 (87.3%). Follow-up swab turned positive in 13 of 32 patients. Using chest CT at admission as gold standard on the entire study population of 539 patients, nasopharyngeal swab had 80% accuracy. Comorbidity network analysis revealed a more homogenous distribution 60–40 aged SARS-COV-2 patients across diseases and a crucial different interplay of diseases in the networks of deceased and survived patients. SARS-CoV-2 caused high mortality among patients older than 60 years and correlated with pre-existing multiorgan impairment. Public Library of Science 2021-03-25 /pmc/articles/PMC7993836/ /pubmed/33765013 http://dx.doi.org/10.1371/journal.pone.0248498 Text en © 2021 Gili et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Gili, Tommaso
Benelli, Giampaolo
Buscarini, Elisabetta
Canetta, Ciro
La Piana, Giuseppe
Merli, Guido
Scartabellati, Alessandro
Viganò, Giovanni
Sfogliarini, Roberto
Melilli, Giovanni
Assandri, Roberto
Cazzato, Daniele
Rossi, Davide Sebastiano
Usai, Susanna
Caldarelli, Guido
Tramacere, Irene
Pellegata, Germano
Lauria, Giuseppe
SARS-COV-2 comorbidity network and outcome in hospitalized patients in Crema, Italy
title SARS-COV-2 comorbidity network and outcome in hospitalized patients in Crema, Italy
title_full SARS-COV-2 comorbidity network and outcome in hospitalized patients in Crema, Italy
title_fullStr SARS-COV-2 comorbidity network and outcome in hospitalized patients in Crema, Italy
title_full_unstemmed SARS-COV-2 comorbidity network and outcome in hospitalized patients in Crema, Italy
title_short SARS-COV-2 comorbidity network and outcome in hospitalized patients in Crema, Italy
title_sort sars-cov-2 comorbidity network and outcome in hospitalized patients in crema, italy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993836/
https://www.ncbi.nlm.nih.gov/pubmed/33765013
http://dx.doi.org/10.1371/journal.pone.0248498
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