Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis

While transcripts of neuronal mitochondrial genes are strongly suppressed in central nervous system inflammation, it is unknown whether this results in mitochondrial dysfunction and whether an increase of mitochondrial function can rescue neurodegeneration. Here, we show that predominantly genes of...

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Detalles Bibliográficos
Autores principales: Rosenkranz, Sina C, Shaposhnykov, Artem A, Träger, Simone, Engler, Jan Broder, Witte, Maarten E, Roth, Vanessa, Vieira, Vanessa, Paauw, Nanne, Bauer, Simone, Schwencke-Westphal, Celina, Schubert, Charlotte, Bal, Lukas Can, Schattling, Benjamin, Pless, Ole, van Horssen, Jack, Freichel, Marc, Friese, Manuel A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993994/
https://www.ncbi.nlm.nih.gov/pubmed/33565962
http://dx.doi.org/10.7554/eLife.61798

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