Human ORC/MCM density is low in active genes and correlates with replication time but does not delimit initiation zones

Eukaryotic DNA replication initiates during S phase from origins that have been licensed in the preceding G1 phase. Here, we compare ChIP-seq profiles of the licensing factors Orc2, Orc3, Mcm3, and Mcm7 with gene expression, replication timing, and fork directionality profiles obtained by RNA-seq, R...

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Detalles Bibliográficos
Autores principales: Kirstein, Nina, Buschle, Alexander, Wu, Xia, Krebs, Stefan, Blum, Helmut, Kremmer, Elisabeth, Vorberg, Ina M, Hammerschmidt, Wolfgang, Lacroix, Laurent, Hyrien, Olivier, Audit, Benjamin, Schepers, Aloys
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993996/
https://www.ncbi.nlm.nih.gov/pubmed/33683199
http://dx.doi.org/10.7554/eLife.62161

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