Cargando…

Common Variants in the TMPRSS6 Gene Alter Hepcidin but not Plasma Iron in Response to Oral Iron in Healthy Gambian Adults: A Recall-by-Genotype Study

BACKGROUND: The role of genetic determinants in mediating iron status in Africans is not fully understood. Genome-wide association studies in non-African populations have revealed genetic variants in the transmembrane protease serine 6 gene (TMPRSS6) that are associated with the risk of anemia. OBJE...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jallow, Momodou W, Campino, Susana, Saidykhan, Alasana, Prentice, Andrew M, Cerami, Carla
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994066/ https://www.ncbi.nlm.nih.gov/pubmed/33817543 http://dx.doi.org/10.1093/cdn/nzab014

Ejemplares similares

Association of common TMPRSS6 and TF gene variants with hepcidin and iron status in healthy rural Gambians
por: Jallow, Momodou W., et al.
Publicado: (2021)

Differences in the frequency of genetic variants associated with iron imbalance among global populations
por: Jallow, Momodou W., et al.
Publicado: (2020)

The effect of BCG on iron metabolism in the early neonatal period: A controlled trial in Gambian neonates
por: Prentice, Sarah, et al.
Publicado: (2015)

Respiratory infections drive hepcidin-mediated blockade of iron absorption leading to iron deficiency anemia in African children
por: Prentice, Andrew M., et al.
Publicado: (2019)

Rapid growth is a dominant predictor of hepcidin suppression and declining ferritin in Gambian infants
por: Armitage, Andrew E., et al.
Publicado: (2019)

Hepcidin mediates hypoferremia and reduces the growth potential of bacteria in the immediate post-natal period in human neonates
por: Prentice, Sarah, et al.
Publicado: (2019)

The A736V TMPRSS6 polymorphism influences hepcidin and iron metabolism in chronic hemodialysis patients: TMPRSS6 and hepcidin in hemodialysis
por: Pelusi, Serena, et al.
Publicado: (2013)

Iron homeostasis in full-term, normal birthweight Gambian neonates over the first week of life
por: Cross, James H., et al.
Publicado: (2023)

Hepcidin and iron-mediated resistance to malaria
por: Prentice, Andrew M
Publicado: (2011)

Hepcidin-guided screen-and-treat interventions for young children with iron-deficiency anaemia in The Gambia: an individually randomised, three-arm, double-blind, controlled, proof-of-concept, non-inferiority trial
por: Wegmüller, Rita, et al.
Publicado: (2022)

Iron supplementation of breastfed Gambian infants from 6 weeks to 6 months of age: protocol for a randomised controlled trial
por: Stelle, Isabella, et al.
Publicado: (2022)

Hepcidin, Serum Iron, and Transferrin Saturation in Full-Term and Premature Infants during the First Month of Life: A State-of-the-Art Review of Existing Evidence in Humans
por: Cross, James H, et al.
Publicado: (2020)

Iron status and fibroblast growth factor-23 in Gambian children
por: Braithwaite, Vickie, et al.
Publicado: (2012)

Elevated Hepcidin Is Part of a Complex Relation That Links Mortality with Iron Homeostasis and Anemia in Men and Women with HIV Infection(1)(2)(3)
por: Minchella, Peter A, et al.
Publicado: (2015)

Thiamine deficiency in Gambian women of reproductive age
por: Bourassa, Megan W., et al.
Publicado: (2021)

Serum Hepcidin Concentrations Decline during Pregnancy and May Identify Iron Deficiency: Analysis of a Longitudinal Pregnancy Cohort in The Gambia(1)(2)(3)
por: Bah, Amat, et al.
Publicado: (2017)

A double blind randomised controlled trial comparing standard dose of iron supplementation for pregnant women with two screen-and-treat approaches using hepcidin as a biomarker for ready and safe to receive iron
por: Bah, Amat, et al.
Publicado: (2016)

Oral iron acutely elevates bacterial growth in human serum
por: Cross, James H., et al.
Publicado: (2015)

Associations of Common Variants in HFE and TMPRSS6 Genes with Hepcidin-25 and Iron Status Parameters in Patients with End-Stage Renal Disease
por: Dopsaj, Violeta, et al.
Publicado: (2019)

Transferrin Saturation/Hepcidin Ratio Discriminates TMPRSS6-Related Iron Refractory Iron Deficiency Anemia from Patients with Multi-Causal Iron Deficiency Anemia
por: van der Staaij, Hilde, et al.
Publicado: (2022)

Interferon-gamma polymorphisms and risk of iron deficiency and anaemia in Gambian children
por: Abuga, Kelvin M., et al.
Publicado: (2020)

Clinical manifestation, staging and prognosis of hepatocellular carcinoma in Gambian patients
por: Bittaye, Sheikh Omar, et al.
Publicado: (2023)

mRNA Levels of Placental Iron and Zinc Transporter Genes Are Upregulated in Gambian Women with Low Iron and Zinc Status
por: Jobarteh, Modou Lamin, et al.
Publicado: (2017)

Iron, anemia and hepcidin in malaria
por: Spottiswoode, Natasha, et al.
Publicado: (2014)

Iron, hepcidin, and the metal connection
por: Loréal, Olivier, et al.
Publicado: (2014)

Hepcidin and Iron in Health and Disease
por: Nemeth, Elizabeta, et al.
Publicado: (2023)

Hepcidin and Iron Homeostasis in Patients with Subacute Thyroiditis and Healthy Subjects
por: Hernik, Aleksandra, et al.
Publicado: (2019)

Iron metabolism and iron disorders revisited in the hepcidin era
por: Camaschella, Clara, et al.
Publicado: (2020)

Common variants in TMPRSS6 are associated with iron status and erythrocyte volume
por: Benyamin, Beben, et al.
Publicado: (2009)

Adherence of Gambian Diets to EAT-Lancet Diet Recommendations for Health and Sustainability
por: Ali, Zakari, et al.
Publicado: (2022)

Serum hepcidin levels and iron parameters in children with iron deficiency
por: Choi, Hyoung Soo, et al.
Publicado: (2012)

Hepcidin-guided screen-and-treat interventions against iron-deficiency anaemia in pregnancy: a randomised controlled trial in The Gambia
por: Bah, Amat, et al.
Publicado: (2019)

Haematological measurements and iron levels in HIV-infected Gambian subjects
por: Bah, Gibril, et al.
Publicado: (2006)

Hepcidin and the iron enigma in HCV infection
por: Georgopoulou, Urania, et al.
Publicado: (2014)

Hepcidin and Iron Homeostasis during Pregnancy
por: Koenig, Mary Dawn, et al.
Publicado: (2014)

Hepcidin: regulation of the master iron regulator
por: Rishi, Gautam, et al.
Publicado: (2015)

Hepcidin and Its Role in Iron Homeostasis
por: Kwapisz, Justyna, et al.
Publicado: (2009)

The dynamics of nasopharyngeal streptococcus pneumoniae carriage among rural Gambian mother-infant pairs
por: Darboe, Momodou K, et al.
Publicado: (2010)

Hepcidin is the major predictor of erythrocyte iron incorporation in anemic African children
por: Prentice, Andrew M., et al.
Publicado: (2012)

Urinary Hepcidin Levels in Iron-Deficient and Iron-Supplemented Piglets Correlate with Hepcidin Hepatic mRNA and Serum Levels and with Body Iron Status
por: Staroń, Robert, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_o1tbd36huoaamurnjkigau2blg